Serum miR-503 is a Candidate Biomarker for Differentiating Metabolic Healthy Obesity from Metabolic Unhealthy Obesity
Serum miR-503 is a Candidate Biomarker for Differentiating Metabolic Healthy Obesity from Metabolic Unhealthy Obesity
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血清 miR-503 是区分代谢性健康肥胖和代谢性不健康肥胖的候选生物标志物
DOI：
10.2147/dmso.s262888
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Zhou Hou-De
中科院分区：
文献类型：
--
作者：
Yue Hai-Qing;Zhou Ying-Hui;Guo Yue;Chen-Yi Tang;Wang Fang;Zhou Hou-De
目的 超重和肥胖与代谢疾病有关。然而，超重/肥胖人群的一个亚组并不存在代谢异常。因此，迫切需要找到能够区分不同肥胖表型和代谢状态的生物标志物。患者和方法 总共 98 名个体被分为三组：代谢健康正常体重 (MHNW)、代谢健康肥胖 (MHO) 和代谢不健康肥胖 (MUO)。对参与者的人体测量和生化参数以及血清 BMPR1A 浓度和 miR-503 水平进行评估。进行受试者工作特征（ROC）曲线分析和逻辑回归分析。结果MHO组miR-503水平显着高于MUO组，而MHNW组和MHO组之间无差异。同时，三组之间血清BMPR1A浓度没有观察到显着差异。 ROC曲线分析表明miR-503可以作为区分MUO和MHO的标志物。 Logistic回归分析表明，miR-503是与超重/肥胖受试者不健康代谢状态相关的重要相关因素。结论 miR-503可作为区分MUO和MHO的合适生物标志物，其可能是超重/肥胖受试者代谢紊乱发生的相关因素。
Purpose Overweight and obesity are associated with metabolic diseases. However, a subgroup of the overweight/obese population does not present metabolic abnormalities. Hence, there is an urgent need to identify biomarkers that can distinguish different obesity phenotypes and metabolic status. Patients and Methods A total of 98 individuals were divided into three groups: metabolically healthy normal weight (MHNW), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Participants were evaluated for anthropometric and biochemical parameters and serum BMPR1A concentration and miR-503 level. Receiver operating characteristic (ROC) curve analysis and logistic regression analysis were performed. Results The level of miR-503 was significantly higher in the MHO group compared with that in the MUO group, but no difference was observed between the MHNW and MHO groups. Meanwhile, no significant differences in serum BMPR1A concentration were observed between the three groups. ROC curve analysis showed that miR-503 could be used as a marker to distinguish the MUO from the MHO. Logistic regression analysis suggested that miR-503 was an important related factor associated with an unhealthy metabolic state in overweight/obese subjects. Conclusion miR-503 can be considered as a suitable biomarker to distinguish between the MUO and MHO, which may be a related factor for the incidence of metabolic disorders in overweight/obese subjects.
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影响因子：
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作者：
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DOI：
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DOI：
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发表时间：
2016-06
期刊：
Obesity (Silver Spring, Md.)
影响因子：
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