Selenium and glutathione peroxidase levels in patients with epidermoid carcinoma of the oral cavity and oropharynx
Selenium and glutathione peroxidase levels in patients with epidermoid carcinoma of the oral cavity and oropharynx
复制标题
口腔和口咽表皮样癌患者的硒和谷胱甘肽过氧化物酶水平
作者：
W. Goodwin;H. Lane;Kathleen Bradford;M. V. Marshall;A. Griffin;H. Geopfert;R. Jesse
硒摄入可抑制致癌作用。流行病学研究表明，在土壤和饲料作物含硒水平较高的州，大多数头颈部癌症的年龄调整死亡率较低。其作用机制尚不完全清楚，但可能通过增加硒依赖性抗氧化酶谷胱甘肽过氧化物酶（GSH-Px）的活性介导。作者研究了50名未经治疗的口腔和口咽癌患者的血硒水平以及血液和组织GSH‐Px活性。与年龄匹配的对照组相比，平均红细胞硒和谷胱甘肽过氧化物酶显著降低。另一方面，平均血浆硒在癌症患者组中显著升高。还讨论了癌症患者组内子集的数据。GSH-Px活性在肿瘤和邻近正常组织中没有差异。用抑制性化合物化学预防癌变的概念特别适合于头颈癌的控制。进一步的工作表明，以确定补充硒的摄入是否纠正这里确定的异常，以及什么影响，如果有的话，这将对上呼吸消化道鳞状细胞癌的发展和行为。
Selenium ingestion may inhibit carcinogenesis. Epidemiologic studies have shown that age‐adjusted death rates for cancer at most head and neck sites are lower in states where the soil and forage crops contain higher levels of selenium. The mode of action is incompletely understood, but may be mediated through an increase in the activity of the selenium dependent, antioxidant enzyme glutathione peroxidase (GSH‐Px). The authors studied blood selenium levels and blood and tissue GSH‐Px activities in 50 patients with untreated cancer of the oral cavity and oropharynx. Mean erythrocyte selenium and glutathione peroxidase were significantly depressed when compared to age‐matched controls. Mean plasma selenium, on the other hand, was significantly elevated in the cancer patient group. Data from subsets within the cancer patient group were also discussed. GSH‐Px activity did not differ in tumor and adjacent normal tissue. The concept of chemoprevention of carcinogenesis with inhibitory chemical compounds is particularly apropos to head and neck cancer control. Further work is indicated to determine if ingestion of supplemental selenium corrects the abnormalities identified here, and what affect, if any, this would have on the development and behavior of squamous cell cancers in the upper aerodigestive tract.
硒介导的小鼠乳腺肿瘤发生的抑制。
影响因子：
9.7
作者：
Medina,D;Shepherd,F
通讯作者：
Shepherd,F