Involvement of the Brain Noradrenaline System in Emotional Changes Caused by Stress in Rats a
Involvement of the Brain Noradrenaline System in Emotional Changes Caused by Stress in Rats a
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大脑去甲肾上腺素系统参与大鼠应激引起的情绪变化
DOI：
10.1111/j.1749-6632.1990.tb16165.x
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发表时间：
1990
影响因子：
5.2
通讯作者：
H. Nishimura
中科院分区：
文献类型：
--
作者：
Masatoshi Tanaka;A. Tsuda;H. Yokoo;Masami Yoshida;Y. Ida;H. Nishimura
研究表明，多种应激刺激可引起啮齿类动物脑区去甲肾上腺素（NA）释放增加。'.“人们试图阐明大脑NA系统神经元活动增强的生理意义。这些变化被认为与内分泌系统和自主神经系统的功能有关。此外，有一种假说认为，大脑NA系统的神经元激活，特别是蓝斑（LC），在焦虑和/或恐惧的激发中起着重要作用：焦虑的NA假说。最近，有报道称，0-咔啉类化合物会引起人类焦虑，10”，以及暗示焦虑的行为。'^.这些药物的神经化学作用可能与激发焦虑和/或恐惧的基本机制密切相关。由于越来越多的人患有焦虑症，因此阐明焦虑的神经化学机制和抗焦虑药物治疗这些患者的药理学机制是非常重要的。本报告的重点是几种不同的压力和药理学的修改和这些增加的意义，特别是它们的关系苯二氮卓类抗焦虑药和阿片类药物引起的大鼠脑区域的NA释放增加的表征。在大鼠脑内，NA神经元胞体主要位于蓝斑和外侧被盖区，神经纤维从这些区域投射到全脑。“神经冲动流释放的NA最终代谢为3-甲氧基-4-羟基苯基乙二醇（MHPG）或3，4-二氢-
It has been well documentated that a variety of stressful stimuli cause increases in noradrenaline ( N A ) release in the brain regions of rodents.'.' Attempts have been made to clarify the physiological significance of enhancement of the neuronal activity of the brain NA system. These changes have been considered to be related to functions of the endocrine system and the autonomic nervous system. Moreover, there has been a hypothesis that neuronal activation of the brain NA system-in particular, the locus coeruleus (LC)-has an important role in the provocation of anxiety and/or fear: the NA hypothesis of anxiety.'-' Recently, 0-carbolines have been reported to cause anxiety in humans,10," and behaviors suggestive of anxiety in and rat^.'^.'^ The neurochemical effects of these drugs might be closely related to the fundamental mechanism of provocation of anxiety and/or fear. Since an increasing number of people suffer from anxiety,I6 it is very important to clarify the neurochemical mechanism of anxiety and the pharmacological mechanism of anxiolytic drugs for the treatment of these patients. This report focuses on the characterization of increases in NA release in rat brain regions caused by several different stresses and the pharmacological modifications and significance of these increases-in particular, their relationship to benzodiazepine anxiolytics and opioid agents. In the rat brain, cell bodies of NA-containing neurons are located mainly in the locus coeruleus and the lateral tegmental areas, from which the nerve fibers are projected to the whole brain regions." NA released by nerve impulse flow is finally metabolized to 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) or 3,4-dihydrox-
苯二氮卓类药物会减弱蓝斑的单个单位活性。
影响因子：
6.1
作者：
Grant,SJ;Huang,YH;RedmondJr,DE
通讯作者：
RedmondJr,DE
3-甲氧基-4-(4-硝基-苯甲氧基)-苯甲醛。
DOI：
10.1107/s1600536808036015
发表时间：
2008
期刊：
Acta crystallographica. Section E, Structure reports online
影响因子：
--
作者：
Li,Mei;Chen,Xin
通讯作者：
Chen,Xin