Per- and Polyfluoroalkyl Substances (PFAS): Significance and Considerations within the Regulatory Framework of the USA.
Per- and Polyfluoroalkyl Substances (PFAS): Significance and Considerations within the Regulatory Framework of the USA.
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DOI：
10.3390/ijerph182111142
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发表时间：
2021-10-23
影响因子：
--
通讯作者：
Wilson M
中科院分区：
文献类型：
--
作者：
Langenbach B;Wilson M
全氟烷基和多氟烷基物质（PFAS）是一种新出现的环境危机。被认为是永久的化学物质，许多同系物在生物中积累，并且由于存在强碳氟共价键而在环境中具有令人难以置信的持久性。值得注意的PFAS化合物包括全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）和GenX。这些物质的毒理学知识非常丰富，但基于这些知识的监管决策已经落后。美国环境保护署（EPA）通过PFAS行动计划和EPA PFAS理事会解决了这一问题，但严重缺乏监管框架。目前，没有任何联邦法规或标准。许多职业和非职业的人类队列存在，可以提供有关PFAS的环境影响和相关健康影响的知识。在职业上，由于使用含有水性成膜泡沫（AFFF）的PFAS和个人防护设备污染，消防员面临重大的暴露风险。北卡罗来纳州的非职业性废水排放导致居民通过饮用水污染长期广泛暴露于GenX。这篇公共卫生综述旨在传达PFAS作为一种环境污染物的当前和未来意义，在美国的监管框架上提供考虑因素，并帮助指导和促进未来流行病学研究的需要，以应对这一环境紧急情况。虽然PFAS行动计划创造了一个科学和监管基础，但重要的是要吸取这些教训并将其应用于未来的环境健康问题。
Per- and polyfluoroalkyl substances (PFAS) are an emerging environmental crisis. Deemed forever chemicals, many congeners bioaccumulate and are incredibly persistent in the environment due to the presence of the strong carbon-fluorine covalent bonds. Notable PFAS compounds include perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and GenX. Robust toxicological knowledge exists for these substances, but regulatory decisions based on this knowledge has fallen behind. The United States Environmental Protection Agency (EPA) has addressed this issue with the PFAS Action Plan and EPA Council on PFAS, but the regulatory framework is severely lacking. Currently, no federal regulations or standards exist. Many occupational and non-occupational human cohorts exist that can lend knowledge on the environmental implications of PFAS and associated health effects. Occupationally, firefighters face significant exposure risks due to use of PFAS containing aqueous film-forming foams (AFFFs) and personal protective equipment contamination. Non-occupationally, wastewater discharge in North Carolina led to chronic and widespread residential exposure to GenX via drinking water contamination. This public health review seeks to convey the current and future significance of PFAS as an environmental contaminate, to lend considerations on regulatory frameworks within the USA, and to help guide and promote the need for future epidemiological studies in order to tackle this environmental emergency. While the PFAS Action Plan creates a scientific and regulatory foundation, it is important to take these lessons and apply them to future environmental health issues.
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影响因子：
4.5
作者：
Butenhoff, John L.;Chang, Shu-Ching;Thomford, Peter J.
通讯作者：
Thomford, Peter J.
DOI：
10.1039/d0em00355g
发表时间：
2020-12-16
期刊：
Environmental science. Processes & impacts
影响因子：
--
作者：
Cousins IT;DeWitt JC;Glüge J;Goldenman G;Herzke D;Lohmann R;Ng CA;Scheringer M;Wang Z
通讯作者：
Wang Z
影响因子：
10.4
作者：
Grandjean P;Heilmann C;Weihe P;Nielsen F;Mogensen UB;Budtz-Jørgensen E
通讯作者：
Budtz-Jørgensen E
产前 PFOS 暴露诱导大鼠后代肺氧化应激和细胞凋亡
影响因子：
3.3
作者：
Chen, Tian;Zhang, Ling;Xu, Shun-qing
通讯作者：
Xu, Shun-qing
影响因子：
3.8
作者：
Butenhoff, J;Costa, G;Thomford, P
通讯作者：
Thomford, P