Risk factors for colon cancer in Northeastern Thailand: interaction of MTHFR codon 677 and 1298 genotypes with environmental factors.
Risk factors for colon cancer in Northeastern Thailand: interaction of MTHFR codon 677 and 1298 genotypes with environmental factors.
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DOI：
10.2188/jea.je20090140
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发表时间：
2010
影响因子：
4.7
通讯作者：
Tokudome S
中科院分区：
文献类型：
--
作者：
Promthet SS;Pientong C;Ekalaksananan T;Wiangnon S;Poomphakwaen K;Songserm N;Chopjitt P;Moore MA;Tokudome S
亚甲基四氢叶酸还原酶（MTHFR）的多态性，如MTHFR C677T和A1298C，与几种癌症有关。本研究旨在评估泰国东北部人群中MTHFR多态性对结肠癌风险的影响及其与环境因素的可能相互作用。这项以医院为基础的病例对照研究于2002-2006年进行；130名结肠癌患者和130名年龄和性别匹配的对照组被纳入研究。收集资料，采集血样，采用限制性片段长度多态性聚合酶链反应技术检测MTHFR C677T和A1298C多态性。使用条件逻辑回归评估感兴趣的变量与结肠癌之间的关联。结肠癌风险的增加与饮酒和排便习惯有关。每天饮酒量≤0.50或0.50单位的饮酒者有较高的风险（ORadj = 3.5； 95% CI分别为1.19-10.25和1.71；95% CI分别为0.74-3.96）。经常便秘（11.69;2.18-62.79）和偶尔便秘（3.43;1.72-6.82）的受试者的风险也更高。MTHFR C677T多态性与淡水鱼食用量对结肠癌风险的影响存在交互作用（交互作用P值= 0.031）。MTHFR A1298C多态性与排便习惯、癌症家族史、饮酒和牛肉消费对结肠癌风险存在交互作用（交互作用的p值分别为0.0005、0.007、0.067、0.003）。在泰国人群中，结肠癌风险与酒精和牛肉消费、排便习惯和癌症家族史有关。MTHFR多态性与环境因子之间的相互作用也被观察到。
Polymorphisms in methylenetetrahydrofolate reductase (MTHFR), such as MTHFR C677T and A1298C, are associated with several cancers. This study aimed to evaluate the effects of MTHFR polymorphisms on colon cancer risk and possible interactions with environmental factors in a population from northeastern Thailand. This hospital-based case–control study was conducted during 2002–2006; 130 colon cancer cases and 130 age- and sex-matched controls were enrolled. Information was collected and blood samples were obtained for assay of MTHFR C677T and A1298C polymorphisms by polymerase chain reaction with restriction fragment length polymorphism techniques. Associations between variables of interest and colon cancer were assessed using conditional logistic regression. Increased risk of colon cancer was associated with alcohol consumption and bowel habits. Alcohol drinkers who consumed ≤0.50 or >0.50 units of alcohol per day had elevated risks (ORadj = 3.5; 95% CI: 1.19–10.25 and ORadj = 1.71; 95% CI: 0.74–3.96, respectively). The risk was also higher in subjects with frequent constipation (11.69; 2.18–62.79) and occasional constipation (3.43; 1.72–6.82). An interaction was observed between the MTHFR C677T polymorphism and freshwater fish consumption on colon cancer risk (P value for interaction = 0.031). Interactions were observed between the MTHFR A1298C polymorphism and bowel habits, family history of cancer, alcohol consumption, and beef consumption on colon cancer risk (P-value for interaction = 0.0005, 0.007, 0.067, 0.003, respectively). In a Thai population, colon cancer risk was associated with alcohol and beef consumption, bowel habits, and family history of cancer. Interactions between MTHFR polymorphisms and environmental factors were also observed.
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影响因子：
158.5
作者：
GIOVANNUCCI, E;EGAN, KM;SPEIZER, FE
通讯作者：
SPEIZER, FE
影响因子：
9.7
作者：
Kim, DH;Ahn, YO;Kono, S
通讯作者：
Kono, S
影响因子：
4.7
作者：
Esteller, M;Garcia, A;Reventos, J
通讯作者：
Reventos, J
影响因子：
4.2
作者：
Choi, SW;Mason, JB
通讯作者：
Mason, JB
影响因子：
2.3
作者：
Hermann, Silke;Rohrmann, Sabine;Linseisen, Jakob
通讯作者：
Linseisen, Jakob