Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs.
Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs.
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DOI：
10.1007/s00018-021-03889-5
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Nurjadi D
中科院分区：
文献类型：
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作者：
Boutin S;Hildebrand D;Boulant S;Kreuter M;Rüter J;Pallerla SR;Velavan TP;Nurjadi D
SARS-CoV-2是导致当今世界面临的重大流行病的病毒。虽然SARS-CoV-2主要引起肺部感染，但各种症状已证明对身体有全身影响。SARS-CoV-2病毒在社区迅速传播，感染了所有年龄、种族和性别的人。然而，致命的结果与特定的宿主因素和共病有关，如年龄、高血压、免疫缺陷、慢性肺部疾病或代谢紊乱。还观察到2019年冠状病毒病(新冠肺炎)患者的微生物组发生重大变化，并与该疾病的最糟糕结局有关。因为已知许多共病与微生物组的失调有关，如高血压、糖尿病和代谢紊乱。宿主因素和微生物群的变化被认为是感染的获得和疾病发展的网络。本文将对SARS-CoV-2感染的免疫应答以及促进和恶化感染的宿主因素进行详细的综述。我们还将讨论新冠肺炎对宿主微生物群和继发感染的影响，后者也会加剧疾病。
SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host’s microbiome and secondary infection which also worsen the disease.
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影响因子：
3.1
作者：
Archer, Nathan K.;Harro, Janette M.;Shirtliff, Mark E.
通讯作者：
Shirtliff, Mark E.
DOI：
10.2147/dmso.s67400
发表时间：
2014
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
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作者：
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影响因子：
6.7
作者：
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通讯作者：
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影响因子：
18.2
作者：
Amraei, Razie;Yin, Wenqing;Rahimi, Nader
通讯作者：
Rahimi, Nader
影响因子：
64.8
作者：
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