Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes.
Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes.
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DOI：
10.1371/journal.pbio.3001586
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发表时间：
2022-04
期刊：
影响因子：
9.8
通讯作者：
中科院分区：
文献类型：
--
作者：
许多成人组织由分化的细胞和干细胞组成，在生理细胞更新过程中，每一种细胞都以协调的方式维持组织的稳态。老分化细胞被认为是典型的凋亡死亡。在这里，我们在成年果蝇的肠道细胞中发现了一种以前未被描述的新现象，我们根据古希腊单词erebos（“完全黑暗”）将其命名为erebosis。经历蜕变的细胞失去了细胞骨架、细胞粘附、细胞器和荧光蛋白，但积累了血管紧张素转换酶（Ance）。它们的细胞核变得扁平，有时难以探测。内皮细胞不具有细胞凋亡、坏死或细胞自噬性死亡的特征。抑制细胞凋亡既不能阻止肠细胞的更新，也不能阻止肠细胞的坏死。我们假设代谢是肠细胞通量介导肠道组织稳态的一种细胞死亡机制。人们一直认为肠道细胞是通过细胞凋亡不断死亡的。然而，这项研究表明，肠道细胞的死亡是通过一种新的细胞死亡机制，被称为erebosis。Erobotic细胞缺乏细胞凋亡、坏死或自噬性死亡的特征；相反，它们失去了细胞骨架、细胞粘附和细胞器，细胞核变得扁平而模糊。
Many adult tissues are composed of differentiated cells and stem cells, each working in a coordinated manner to maintain tissue homeostasis during physiological cell turnover. Old differentiated cells are believed to typically die by apoptosis. Here, we discovered a previously uncharacterized, new phenomenon, which we name erebosis based on the ancient Greek word erebos (“complete darkness”), in the gut enterocytes of adult Drosophila. Cells that undergo erebosis lose cytoskeleton, cell adhesion, organelles and fluorescent proteins, but accumulate Angiotensin-converting enzyme (Ance). Their nuclei become flat and occasionally difficult to detect. Erebotic cells do not have characteristic features of apoptosis, necrosis, or autophagic cell death. Inhibition of apoptosis prevents neither the gut cell turnover nor erebosis. We hypothesize that erebosis is a cell death mechanism for the enterocyte flux to mediate tissue homeostasis in the gut. It has been believed that gut enterocytes continuously die through apoptosis. However, this study shows that gut enterocytes die through a novel cell death mechanism, named erebosis. Erobotic cells lack the characteristic features of apoptotic, necrotic or autophagic cell death; instead they lose their cytoskeleton, cell adhesion and organelles, and their nuclei become flat and indistinct.
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影响因子：
7.7
作者：
Nishida H;Okada M;Yang L;Takano T;Tabata S;Soga T;Ho DM;Chung J;Minami Y;Yoo SK
通讯作者：
Yoo SK
影响因子：
4.8
作者：
CORNEL, MJ;WILLIAMS, TA;ISAAC, RE
通讯作者：
ISAAC, RE
DOI：
10.1046/j.1432-1327.1998.2570599.x
发表时间：
1998-11-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Houard, X;Williams, TA;Corvol, P
通讯作者：
Corvol, P
影响因子：
2.5
作者：
deTorres, C;Munell, F;Macaya, A
通讯作者：
Macaya, A
影响因子：
48
作者：
Balleza E;Kim JM;Cluzel P
通讯作者：
Cluzel P