Parental chest computerized tomography examination before IVF/ICSI has no impact on pregnancy and neonatal outcomes: a cohort study of 2680 fresh transfer cycles.
Parental chest computerized tomography examination before IVF/ICSI has no impact on pregnancy and neonatal outcomes: a cohort study of 2680 fresh transfer cycles.
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IVF/ICSI 前父母胸部计算机断层扫描检查对妊娠和新生儿结局没有影响：2680 个新鲜移植周期的队列研究
DOI：
10.1186/s12884-022-05297-4
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发表时间：
2022-12-26
影响因子：
3.1
通讯作者：
Jin, Lei
中科院分区：
文献类型：
--
作者：
Wang, Lan;Li, Linshuang;Zhao, Yiqing;Xu, Bei;Yue, Jing;Zhang, Hanwang;Jin, Lei
背景IVF/ICSI治疗前的放射学评估中，低水平电离辐射暴露的负面影响引起了一些关注，但现有证据有限且相互矛盾。本研究的目的是评估在IVF/ICSI.MethodsThis之前进行胸部计算机断层扫描（CT）的夫妇的妊娠和新生儿结局，这是一项回顾性队列研究，从2019年1月至2020年8月进行了2680 IVF/ICSI新鲜胚胎移植周期。在取卵和精子采集日期前3个月内进行或未进行CT检查的夫妇之间比较生育力结果。流产是主要研究结局，而次要结局包括收集的卵母细胞数量、卵母细胞成熟、正常受精、优质卵裂期胚胎数量、囊胚形成、着床、临床妊娠、异位妊娠、活产、多胎、剖腹产率、孕周、母体产科并发症、出生体重、新生儿性别比和出生缺陷发生率。倾向评分匹配被用来控制潜在的混杂variable.ResultsOf的2680周期包括在这项研究中，夫妇进行CT检查，在731个周期。在1：1倾向评分匹配后，每组包括670个周期。在倾向评分匹配后，比较接受和未接受CT检查组之间的人口统计学和生育相关变量时，我们发现流产率无显著差异（16.99% vs. 15.77%，OR = 1.10，95CI %= 0.74至1.68）。同样，两组的卵母细胞和胚胎发育、植入率（41.99% vs. 40.42%，OR = 1.07，95%CI = 0.87 - 1.31），临床妊娠率（45.67% vs. 44.48%，OR = 1.05，95%CI = 0.85~1.30），异位妊娠发生率（2.94% vs. 1.68%，OR = 1.78，95%CI = 0.59 - 5.36），活产率（36.57%vs.35.67%，OR = 1.04，95%CI = 0.83~1.30）、多胎率、剖宫产率、孕周、结论IVF/ICSI前胸部CT检查对新鲜胚胎移植相关的妊娠和新生儿结局无影响。
BackgroundSome concern has been expressed regarding the negative effects of low-level ionizing radiation exposure in the context of radiological evaluation prior to IVF/ICSI treatment, but the available evidence is limited and conflicting. The aim of this study is to evaluate pregnancy and neonatal outcomes of couples who did chest computed tomography (CT) prior to IVF/ICSI.MethodsThis was a retrospective cohort study of 2680 IVF/ICSI fresh embryo transfer cycles conducted from January 2019 – August 2020. Fertility outcomes were compared between couples that had or had not undergone CT examination within 3 months prior to the date of oocyte retrieval and sperm collection. Miscarriage was the primary study outcome, while secondary outcomes included the number of oocytes collected, oocyte maturation, normal fertilization, number of good quality cleavage stage embryos, blastocyst formation, implantation, clinical pregnancy, ectopic pregnancy, live birth, multiple birth, Cesarean section rates, gestational weeks, maternal obstetric complications, birth weight, newborn sex ratio, and birth defect incidence. Propensity score matching was used to control for potential confounding variables.ResultsOf the 2680 cycles included in this study, couples underwent CT examination in 731 cycles. After 1:1 propensity score matching, 670 cycles were included in each group. When comparing demographic and fertility-related variables between groups that had and had not undergone CT examination after propensity score matching, we detected no significant differences in miscarriage rates (16.99% vs. 15.77%, OR = 1.10, 95CI% = 0.74 to 1.68). Similarly, both groups exhibited comparable oocyte and embryonic development, implantation rates (41.99% vs. 40.42%, OR = 1.07, 95%CI = 0.87 to 1.31), clinical pregnancy rates (45.67% vs. 44.48%, OR = 1.05, 95%CI = 0.85 to 1.30), ectopic pregnancy rates (2.94% vs. 1.68%, OR = 1.78, 95%CI = 0.59 to 5.36), live birth rates (36.57% vs. 35.67%, OR = 1.04, 95%CI = 0.83 to 1.30), multiple birth rates, Cesarean section rates, gestational weeks, maternal obstetric complication rates, and neonatal outcomes.ConclusionsChest CT examination before IVF/ICSI has no impact on pregnancy and neonatal outcomes associated with fresh embryo transfer.Trial registrationNot applicable.
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DOI：
10.1016/j.ijrobp.2015.04.033
发表时间：
2015-08-01
影响因子：
7
作者：
Grewenig, Angelika;Schuler, Nadine;Ruebe, Claudia E.
通讯作者：
Ruebe, Claudia E.
影响因子：
6.7
作者：
Stroud, Jaymeson S.;Mutch, David;Grigsby, Perry W.
通讯作者：
Grigsby, Perry W.
影响因子：
7.2
作者：
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通讯作者：
Wharton, Kurt R.
影响因子：
3.3
作者：
De Santis, M;Di Gianantonio, E;Clementi, M
通讯作者：
Clementi, M
DOI：
10.1016/j.ejmp.2017.09.120
发表时间：
2017-11-01
影响因子：
3.4
作者：
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通讯作者：
Kortesniemi, M.