Agrochemicals increase risk of human schistosomiasis by supporting higher densities of intermediate hosts.
Agrochemicals increase risk of human schistosomiasis by supporting higher densities of intermediate hosts.
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DOI：
10.1038/s41467-018-03189-w
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发表时间：
2018-02-26
影响因子：
16.6
通讯作者：
Rohr JR
中科院分区：
文献类型：
--
作者：
Halstead NT;Hoover CM;Arakala A;Civitello DJ;De Leo GA;Gambhir M;Johnson SA;Jouanard N;Loerns KA;McMahon TA;Ndione RA;Nguyen K;Raffel TR;Remais JV;Riveau G;Sokolow SH;Rohr JR
血吸虫病是一种蜗牛传播的寄生虫病，是发展中国家人类最重要的水传播疾病之一。人血吸虫病向非流行地区的流行和传播的增加一直与农业扩张有关的水资源管理有关。然而，农用化学品污染在人类有害生物传播中的作用仍未得到探讨，尽管有强有力的证据表明农用化学品增加了野生动物的蜗牛传播疾病，预计到2050年全球农用化学品的使用将增加2至5倍。使用现场围隔实验，我们表明，环境相关浓度的肥料，除草剂，杀虫剂，单独和混合物，增加密度的寄生虫感染的蜗牛，通过增加藻类蜗牛吃和蜗牛捕食者的密度降低。流行病学模型表明，这些农业化学品的影响，可以增加传播的寄生虫。确定最大限度地减少疾病风险的农业实践或农用化学品对于满足不断增长的粮食需求并改善人类福祉至关重要。农药可以以意想不到的方式影响人类寄生虫的生命周期。在这里，Halstead等人在围隔实验中表明，农用化学品增加了携带寄生虫的蜗牛的密度，模型分析表明这可能导致人类血吸虫病风险增加。
Schistosomiasis is a snail-borne parasitic disease that ranks among the most important water-based diseases of humans in developing countries. Increased prevalence and spread of human schistosomiasis to non-endemic areas has been consistently linked with water resource management related to agricultural expansion. However, the role of agrochemical pollution in human schistosome transmission remains unexplored, despite strong evidence of agrochemicals increasing snail-borne diseases of wildlife and a projected 2- to 5-fold increase in global agrochemical use by 2050. Using a field mesocosm experiment, we show that environmentally relevant concentrations of fertilizer, a herbicide, and an insecticide, individually and as mixtures, increase densities of schistosome-infected snails by increasing the algae snails eat and decreasing densities of snail predators. Epidemiological models indicate that these agrochemical effects can increase transmission of schistosomes. Identifying agricultural practices or agrochemicals that minimize disease risk will be critical to meeting growing food demands while improving human wellbeing. Agrochemicals can affect the life cycle of human parasites in unexpected ways. Here, Halstead et al. show in mesocosm experiments that agrochemicals increase the density of snails hosting schistosome parasites, and modeling analysis suggests this could lead to increased risk of human schistosomiasis.
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DOI：
10.1007/s001289900979
发表时间：
1999-09-01
影响因子：
2.7
作者：
Baer, KN;Ziegenfuss, MC;Ling, Z
通讯作者：
Ling, Z
影响因子：
4.1
作者：
Baxter, Leilan R.;Moore, Dana L.;Hanson, Mark L.
通讯作者：
Hanson, Mark L.
影响因子：
2.2
作者：
Fournier, David A.;Skaug, Hans J.;Sibert, John
通讯作者：
Sibert, John
影响因子：
8.8
作者：
Halstead, Neal T.;Civitello, David J.;Rohr, Jason R.
通讯作者：
Rohr, Jason R.
DOI：
10.1899/0887-3593(2006)25
发表时间：
2006-09-01
影响因子：
--
作者：
Liess, Antonia;Hillebrand, Helmut
通讯作者：
Hillebrand, Helmut