The Elusive Coreceptors for the SARS-CoV-2 Spike Protein.
The Elusive Coreceptors for the SARS-CoV-2 Spike Protein.
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DOI：
10.3390/v15010067
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发表时间：
2022-12-25
期刊：
影响因子：
--
通讯作者：
Ostrov DA
中科院分区：
文献类型：
--
作者：
Berkowitz RL;Ostrov DA
有证据表明SARS-CoV-2刺突蛋白的N-末端结构域（NTD）与参与病毒进入的宿主辅助受体相互作用。解析共受体的身份具有重要的临床意义，因为它可以为抗病毒药物和候选疫苗的开发提供基础。关注变体（VOC）中的大多数特征性突变发生在NTD和受体结合结构域（RBD）中。与RBD不同，NTD中的突变聚集在刺突蛋白最灵活的部分。已经提出了许多可能的辅助受体，包括各种糖，如神经节苷脂、唾液酸苷脂和硫酸乙酰肝素。蛋白质辅助受体，包括neuropilin-1和富含亮氨酸的重复序列15（LRRC 15），也被提出参与NTD的辅助受体。
Evidence suggests that the N-terminal domain (NTD) of the SARS-CoV-2 spike protein interacts with host coreceptors that participate in viral entry. Resolving the identity of coreceptors has important clinical implications as it may provide the basis for the development of antiviral drugs and vaccine candidates. The majority of characteristic mutations in variants of concern (VOCs) have occurred in the NTD and receptor binding domain (RBD). Unlike the RBD, mutations in the NTD have clustered in the most flexible parts of the spike protein. Many possible coreceptors have been proposed, including various sugars such as gangliosides, sialosides, and heparan sulfate. Protein coreceptors, including neuropilin-1 and leucine-rich repeat containing 15 (LRRC15), are also proposed coreceptors that engage the NTD.
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DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
影响因子：
11.1
作者：
Aggarwal, Anupriya;Akerman, Anouschka;Milogiannakis, Vanessa;Silva, Mariana Ruiz;Walker, Gregory;Stella, Alberto Ospina;Kindinger, Andrea;Angelovich, Thomas;Waring, Emily;Amatayakul-Chantler, Supavadee;Roth, Nathan;Manni, Sandro;Hauser, Thomas;Barnes, Thomas;Condylios, Anna;Yeang, Malinna;Wong, Maureen;Jean, Tyra;Foster, Charles S. P.;Christ, Daniel;Hoppe, Alexandra Carey;Munier, Mee Ling;Darley, David;Churchill, Melissa;Stark, Damien J.;Matthews, Gail;Rawlinson, William D.;Kelleher, Anthony D.;Turville, Stuart G.
通讯作者：
Turville, Stuart G.
影响因子：
3.9
作者：
Gudowska-Sawczuk M;Mroczko B
通讯作者：
Mroczko B
影响因子：
5
作者：
Milanetti E;Miotto M;Di Rienzo L;Nagaraj M;Monti M;Golbek TW;Gosti G;Roeters SJ;Weidner T;Otzen DE;Ruocco G
通讯作者：
Ruocco G
影响因子：
64.8
作者：
Meng B;Abdullahi A;Ferreira IATM;Goonawardane N;Saito A;Kimura I;Yamasoba D;Gerber PP;Fatihi S;Rathore S;Zepeda SK;Papa G;Kemp SA;Ikeda T;Toyoda M;Tan TS;Kuramochi J;Mitsunaga S;Ueno T;Shirakawa K;Takaori-Kondo A;Brevini T;Mallery DL;Charles OJ;CITIID-NIHR BioResource COVID-19 Collaboration;Genotype to Phenotype Japan (G2P-Japan) Consortium;Ecuador-COVID19 Consortium;Bowen JE;Joshi A;Walls AC;Jackson L;Martin D;Smith KGC;Bradley J;Briggs JAG;Choi J;Madissoon E;Meyer KB;Mlcochova P;Ceron-Gutierrez L;Doffinger R;Teichmann SA;Fisher AJ;Pizzuto MS;de Marco A;Corti D;Hosmillo M;Lee JH;James LC;Thukral L;Veesler D;Sigal A;Sampaziotis F;Goodfellow IG;Matheson NJ;Sato K;Gupta RK
通讯作者：
Gupta RK