The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review.
The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review.
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神经毛蛋白-1（NRP-1）在SARS-CoV-2感染中的作用：综述。
DOI：
10.3390/jcm10132772
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发表时间：
2021-06-24
影响因子：
3.9
通讯作者：
Mroczko B
中科院分区：
文献类型：
--
作者：
Gudowska-Sawczuk M;Mroczko B
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)于2019年被发现，是导致全球冠状病毒病19(新冠肺炎)大流行的罪魁祸首。与宿主细胞受体相互作用的主要蛋白质是冠状病毒的Spike-1(S1)亚单位。这个亚基与宿主细胞膜上的受体结合。多项研究表明，神经匹林-1(NRP-1)是SARS-CoV-2进入的辅助受体之一。因此，本文就NRP-1在SARS-CoV-2感染中的意义作一综述。用Medline/PubMed数据库检索现有文献。在目前的综述中，我们报道了NRP-1在许多重要功能中的作用，包括血管生成、神经元发育和免疫反应的调节。此外，宿主细胞膜上这种糖蛋白的存在显著增加了SARS-CoV-2的感染和传播。文献资料表明，NRP-1促进病毒通过鼻腔的嗅觉上皮进入中枢神经系统。此外，已发表的研究结果表明，使用NRP-1抑制剂干扰血管内皮生长因子-A/NRP-1可能产生镇痛作用。该综述描述了NRP-1、SARS-CoV-2和视网膜病变等之间的联系。根据已发表的研究结果，我们认为NRP-1在SARS-CoV-2感染的神经系统表现中是一个非常重要的介质。此外，NRP-1抑制剂的使用似乎是治疗SARS-CoV-2感染的一种有前途的治疗策略。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), discovered in 2019, is responsible for the global coronavirus disease 19 (COVID-19) pandemic. The main protein that interacts with the host cell receptor is the Spike-1 (S1) subunit of the coronavirus. This subunit binds with receptors present on the host cell membrane. It has been identified from several studies that neuropilin-1 (NRP-1) is one of the co-receptors for SARS-CoV-2 entry. Therefore, in this review, we focus on the significance of NRP-1 in SARS-CoV-2 infection. MEDLINE/PubMed database was used for a search of available literature. In the current review, we report that NRP-1 plays many important functions, including angiogenesis, neuronal development, and the regulation of immune responses. Additionally, the presence of this glycoprotein on the host cell membrane significantly augments the infection and spread of SARS-CoV-2. Literature data suggest that NRP-1 facilitates entry of the virus into the central nervous system through the olfactory epithelium of the nasal cavity. Moreover, published findings show that interfering with VEGF-A/NRP-1 using NRP-1 inhibitors may produce an analgesic effect. The review describes an association between NRP-1, SARS-CoV-2 and, inter alia, pathological changes in the retina. Based on the published findings, we suggest that NRP-1 is a very important mediator implicated in, inter alia, neurological manifestations of SARS-CoV-2 infection. Additionally, it appears that the use of NRP-1 inhibitors is a promising therapeutic strategy for the treatment of SARS-CoV-2 infection.
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DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
影响因子：
4.5
作者：
Mihaescu G;Chifiriuc MC;Iliescu C;Vrancianu CO;Ditu LM;Marutescu LG;Grigore R;Berteșteanu Ș;Constantin M;Gradisteanu Pircalabioru G
通讯作者：
Gradisteanu Pircalabioru G
影响因子：
39.3
作者：
Kyrou I;Randeva HS;Spandidos DA;Karteris E
通讯作者：
Karteris E
影响因子：
8.4
作者：
Amzat, Jimoh;Aminu, Kafayat;Danjibo, Maryann C.
通讯作者：
Danjibo, Maryann C.
影响因子：
3.4
作者：
Davies J;Randeva HS;Chatha K;Hall M;Spandidos DA;Karteris E;Kyrou I
通讯作者：
Kyrou I