Does aspirin have a role in venous thromboembolism prophylaxis in total knee arthroplasty patients?
Does aspirin have a role in venous thromboembolism prophylaxis in total knee arthroplasty patients?
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阿司匹林在总膝关节性置换术患者的静脉血栓栓塞预防中是否起作用？
DOI：
10.1016/j.arth.2009.06.021
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发表时间：
2010-10
影响因子：
3.5
通讯作者：
Auerbach, Andrew D.
中科院分区：
文献类型：
--
作者：
Bozic, Kevin J.;Vail, Thomas P.;Pekow, Penelope S.;Maselli, Judith H.;Lindenauer, Peter K.;Auerbach, Andrew D.
关键词：
本研究的目的是比较全膝关节置换术（TKA）中接受阿司匹林或指南批准的静脉血栓栓塞（VTE）预防性治疗（华法林、低分子量肝素、合成五糖）的患者的静脉血栓栓塞（VTE）、出血、手术部位感染和死亡率的风险。我们分析了在24个月内在307家美国医院接受初次TKA的93，840例患者的临床和管理数据。51，923例（55%）患者接受华法林治疗，37，198例（40%）接受注射剂治疗，4，719例（5%）接受阿司匹林治疗。调整患者和医院因素后，接受阿司匹林VTEP的患者血栓栓塞的几率低于华法林患者，但与注射VTEP相比，其几率相似;调整后出血、感染或死亡风险无差异。我们的研究结果表明，阿司匹林，当与其他临床护理方案结合使用，可能是有效的VTEP某些TKA患者。
The objectives of this study were to compare the risk of venous thromboembolism (VTE), bleeding, surgical site infection, and mortality in patients receiving aspirin or guideline-approved VTE prophylactic therapies (warfarin, low-molecular weight heparins, synthetic pentasaccharides) in total knee arthroplasty (TKA). We analyzed clinical and administrative data from 93,840 patients who underwent primary TKA at 307 U.S. hospitals over a 24 month period. 51,923 (55%) patients received warfarin, 37,198 (40%) received injectable agents, and 4,719 (5%) received aspirin. After adjustment for patient and hospital factors, patients who received aspirin VTEP had lower odds for thromboembolism compared to warfarin patients, but similar odds compared to injectable VTEP; there were no differences in risk of bleeding, infection or mortality after adjustment. Our results suggest that aspirin, when used in conjunction with other clinical care protocols, may be effective VTEP for certain TKA patients.
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影响因子：
9.6
作者：
Geerts, WH;Pineo, GF;Ray, JG
通讯作者：
Ray, JG
影响因子：
3.5
作者：
Burnett, R. Stephen J.;Clohisy, John C.;Barrack, Robert L.
通讯作者：
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影响因子：
3
作者：
Elixhauser, A;Steiner, C;Coffey, RN
通讯作者：
Coffey, RN
DOI：
10.2106/00004623-197658070-00006
发表时间：
1976-01-01
影响因子：
5.3
作者：
MCKENNA, R;BACHMANN, F;GALANTE, JO
通讯作者：
GALANTE, JO
影响因子：
158.5
作者：
HARRIS, WH;SALZMAN, EW;DESANCTIS, RW
通讯作者：
DESANCTIS, RW