Emergence of pediatric melioidosis in Siem Reap, Cambodia.
Emergence of pediatric melioidosis in Siem Reap, Cambodia.
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DOI：
10.4269/ajtmh.2010.10-0030
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Peacock SJ
中科院分区：
文献类型：
--
作者：
Pagnarith Y;Kumar V;Thaipadungpanit J;Wuthiekanun V;Amornchai P;Sin L;Day NP;Peacock SJ
我们描述了柬埔寨首例儿童类鼻疽病例。 2005 年 10 月至 2008 年 12 月期间，暹粒吴哥儿童医院引进微生物学能力后诊断出 39 例病例。中位年龄为 7.8 岁（范围 = 1.6-16.2 岁），15 例为男性（38%），4 例患有可能导致患者罹患类鼻疽的既往病史。 27 例（69%）为局部感染，12 例（31%）为播散性感染。门诊11例（28%），入院28例（72%）。八名儿童 (21%) 在入院后中位 2 天死亡；七例死亡归因于类鼻疽，所有死亡均发生在接受次优抗菌治疗且在获得细菌培养结果之前的儿童中。我们的研究结果表明，需要提高柬埔寨对类鼻疽病的认识，这促使我们审查疑似和确诊病例的微生物学程序和抗菌药物处方。
We describe the first cases of pediatric melioidosis in Cambodia. Thirty-nine cases were diagnosed at the Angkor Hospital for Children, Siem Reap, between October 2005 and December 2008 after the introduction of microbiology capabilities. Median age was 7.8 years (range = 1.6–16.2 years), 15 cases were male (38%), and 4 cases had pre-existing conditions that may have pre-disposed the patient to melioidosis. Infection was localized in 27 cases (69%) and disseminated in 12 cases (31%). Eleven cases (28%) were treated as outpatients, and 28 (72%) cases were admitted. Eight children (21%) died a median of 2 days after admission; seven deaths were attributable to melioidosis, all of which occurred in children receiving suboptimal antimicrobial therapy and before bacteriological culture results were available. Our findings indicate the need for heightened awareness of melioidosis in Cambodia, and they have led us to review microbiology procedures and antimicrobial prescribing of suspected and confirmed cases.
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影响因子：
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作者：
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影响因子：
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DOI：
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发表时间：
2008-12-01
影响因子：
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通讯作者：
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