Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits.
Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits.
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DOI：
10.1016/s2215-0366(22)00157-2
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发表时间：
2022-10
影响因子：
64.3
通讯作者：
Davis, Lea K.
中科院分区：
文献类型：
--
作者：
Lencz, Todd;Sabatello, Maya;Docherty, Anna;Peterson, Roseann E.;Soda, Takahiro;Austin, Jehannine;Bierut, Laura;Crepaz-Keay, David;Curtis, David;Degenhardt, Franziska;Huckins, Laura;Lazaro-Munoz, Gabriel;Mattheisen, Manuel;Meiser, Bettina;Peay, Holly;Rietschel, Marcella;Walss-Bass, Consuelo;Davis, Lea K.
私营公司已经开始提供服务，允许接受体外受精的父母筛查胚胎是否有患复杂疾病的遗传风险，包括精神障碍。这一过程被称为多基因胚胎筛选，提出了几个棘手的科学和伦理问题，正如本文所讨论的那样。多基因胚胎筛查依赖于多基因风险分数的统计特性，多基因风险分数是复杂的，在拟议的临床应用背景下没有得到很好的研究。多基因胚胎筛查的临床、社会和伦理影响在相关利益相关者中几乎没有讨论过。据我们所知，国际精神病学遗传学学会是第一个发布关于多基因胚胎筛查的声明的专业生物医学组织。出于个人观点中讨论的原因，该学会敦促谨慎，并呼吁对多基因胚胎筛查的使用进行更多的研究和监督。
Private companies have begun offering services to allow parents undergoing in-vitro fertilisation to screen embryos for genetic risk of complex diseases, including psychiatric disorders. This procedure, called polygenic embryo screening, raises several difficult scientific and ethical issues, as discussed in this Personal View. Polygenic embryo screening depends on the statistical properties of polygenic risk scores, which are complex and not well studied in the context of this proposed clinical application. The clinical, social, and ethical implications of polygenic embryo screening have barely been discussed among relevant stakeholders. To our knowledge, the International Society of Psychiatric Genetics is the first professional biomedical organisation to issue a statement regarding polygenic embryo screening. For the reasons discussed in this Personal View, the Society urges caution and calls for additional research and oversight on the use of polygenic embryo screening.
影响因子：
3.4
作者：
Sabatello M;Chao A;Insel BJ;Corbeil T;Link BG;Appelbaum PS
通讯作者：
Appelbaum PS