Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls.
Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls.
复制标题
eNOS rs1799983多态性与高血压的相关性：一项涉及14185例和13407例对照的荟萃分析
DOI：
10.1186/s12872-021-02192-2
复制
发表时间：
2021-08-09
影响因子：
2.1
通讯作者：
Cheng Y
中科院分区：
文献类型：
--
作者：
Shi J;Liu S;Guo Y;Liu S;Xu J;Pan L;Hu Y;Liu Y;Cheng Y
原发性高血压是由遗传和环境因素共同作用决定的复杂疾病，eNOS被认为是高血压的易感基因之一。本研究旨在探讨eNOS rs1799983多态性与高血压的关系，为高血压的病因学研究提供依据。根据PRISMA指南，检索PubMed、Embase、Web of Science、Medline、Scopus、万方数据库、Vip数据库和中国知网数据库，纳入eNOS rs1799983多态性与高血压的病例对照研究。根据5种不同的遗传模型，使用R软件对符合条件的数据进行提取和汇总，并进行分析。最终筛选出60篇符合条件的文章，涉及14185例病例和13407例对照。我们发现，在任何遗传模型下，eNOS rs1799983多态性与高血压之间都存在显著相关性（T vs G: OR = 1.44, 95% CI 1.26-1.63; GT vs GG: OR 1.34, 95% CI 1.18-1.52; TT vs GG: OR 1.80, 95% CI 1.41-2.31; GT + TT vs GG: OR 1.42, 95% CI 1.25-1.63; TT vs GG + GT: OR 1.68, 95% CI 1.35-2.08; GT vs GG + TT: OR 1.24, 95% CI 1.11-1.40）。我们发现，在任何遗传模型下，eNOS rs1799983多态性都与高血压风险增加相关。此外，为了更深入地了解eNOS rs1799983多态性与高血压之间的关系，还需要研究基因-基因和基因-环境的相互作用。在线版本包含补充材料，可在10.1186/s12872-021-02192-2获得。
Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. Our study aimed to evaluate the association between eNOS rs1799983 polymorphism and hypertension, and to provide evidence for the etiology of hypertension. Case–control studies of eNOS rs1799983 polymorphism and hypertension were included by searching PubMed, Embase, Web of Science, Medline, Scopus, WanFang datebase, Vip datebase, and CNKI database according to PRISMA guideline. Eligible data were extracted and pooled, and were analyzed using R software based on five different genetic models. A total of 60 eligible articles involving 14,185 cases and 13,407 controls were finally selected. We found significant association between eNOS rs1799983 polymorphism and hypertension under any genetic model (T vs G: OR = 1.44, 95% CI 1.26–1.63; GT vs GG: OR 1.34, 95% CI 1.18–1.52; TT vs GG: OR 1.80, 95% CI 1.41–2.31; GT + TT vs GG: OR 1.42, 95% CI 1.25–1.63; TT vs GG + GT: OR 1.68, 95% CI 1.35–2.08; GT vs GG + TT: OR 1.24, 95% CI 1.11–1.40). We found that eNOS rs1799983 polymorphism is associated with the increased risk of hypertension under any genetic model. Moreover, investigations of gene–gene and gene-environment interactions are needed to give more insight into the association between eNOS rs1799983 polymorphism and hypertension. The online version contains supplementary material available at 10.1186/s12872-021-02192-2.
登录
查看更多内容
影响因子：
3.7
作者：
Niu W;Qi Y
通讯作者：
Qi Y
影响因子：
--
作者：
Gamil S;Erdmann J;Abdalrahman IB;Mohamed AO
通讯作者：
Mohamed AO
影响因子：
3.7
作者：
Turner RM;Bird SM;Higgins JP
通讯作者：
Higgins JP
影响因子：
2
作者：
Higgins, Julian P. T.;Whitehead, Anne;Simmonds, Mark
通讯作者：
Simmonds, Mark
影响因子：
1.7
作者：
Liu, Jielin;Wang, Lijuan;Wen, Shaojun
通讯作者：
Wen, Shaojun