Pesticides and Parkinson's disease--is there a link?
Pesticides and Parkinson's disease--is there a link?
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DOI：
10.1289/ehp.8095
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发表时间：
2006-02
影响因子：
10.4
通讯作者：
Levy LS
中科院分区：
文献类型：
--
作者：
Brown TP;Rumsby PC;Capleton AC;Rushton L;Levy LS
帕金森病(PD)是一种以进行性震颤、运动迟缓、僵硬和姿势不稳定为特征的特发性神经系统疾病。推测包括农药在内的外源性毒物可能参与了帕金森病的发病机制。在这篇文章中，我们全面回顾了已发表的流行病学和毒理学文献，并对农药暴露和帕金森病之间是否存在关系进行了批判性评估。从流行病学文献来看，农药暴露和帕金森病之间确实存在相对一致的关系。这种关系在接触除草剂和杀虫剂以及长期接触后表现得最强烈。毒理学数据表明，百草枯和鱼藤酮可能具有神经毒性作用，可能在帕金森病的发展中发挥作用，其他杀虫剂的数据有限。然而，流行病学和毒理学研究都受到方法学缺陷的限制。当前和未来感兴趣的特殊问题包括多重暴露(包括杀虫剂和其他外源毒物)、发育暴露以及基因与环境的相互作用。目前，证据的份量足以得出结论，即农药接触和帕金森病之间存在普遍的联系，但不足以得出结论，这是一种因果关系，或者对于任何特定的农药化合物或组合农药和其他外源毒物暴露存在这种关系。
Parkinson’s disease (PD) is an idiopathic disease of the nervous system characterized by progressive tremor, bradykinesia, rigidity, and postural instability. It has been postulated that exogenous toxicants, including pesticides, might be involved in the etiology of PD. In this article we present a comprehensive review of the published epidemiologic and toxicologic literature and critically evaluate whether a relationship exists between pesticide exposure and PD. From the epidemiologic literature, there does appear to be a relatively consistent relationship between pesticide exposure and PD. This relationship appears strongest for exposure to herbicides and insecticides, and after long durations of exposure. Toxicologic data suggest that paraquat and rotenone may have neurotoxic actions that potentially play a role in the development of PD, with limited data for other pesticides. However, both the epidemiology and toxicology studies were limited by methodologic weaknesses. Particular issues of current and future interest include multiple exposures (both pesticides and other exogenous toxicants), developmental exposures, and gene–environment interactions. At present, the weight of evidence is sufficient to conclude that a generic association between pesticide exposure and PD exists but is insufficient for concluding that this is a causal relationship or that such a relationship exists for any particular pesticide compound or combined pesticide and other exogenous toxicant exposure.
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影响因子：
4.7
作者：
Barlow, BK;Thiruchelvam, MJ;Richfield, EK
通讯作者：
Richfield, EK
影响因子：
--
作者：
Firestone, JA;Smith-Weller, T;Checkoway, H
通讯作者：
Checkoway, H
DOI：
10.1111/j.1600-0773.1992.tb00575.x
发表时间：
1992-12-01
期刊：
PHARMACOLOGY & TOXICOLOGY
影响因子：
--
作者：
BAGETTA, G;CORASANITI, MT;STEPHENSON, JD
通讯作者：
STEPHENSON, JD
影响因子：
3.8
作者：
FREDRIKSSON, A;FREDRIKSSON, M;ERIKSSON, P
通讯作者：
ERIKSSON, P
DOI：
10.1038/sj.jea.7500176
发表时间：
2001-09-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Engel, LS;Seixas, NS;Checkoway, H
通讯作者：
Checkoway, H