Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors.
Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors.
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DOI：
10.2174/1389201011314030010
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发表时间：
2013
影响因子：
2.8
通讯作者：
Ralph SJ
中科院分区：
文献类型：
--
作者：
Hahn T;Polanczyk MJ;Borodovsky A;Ramanathapuram LV;Akporiaye ET;Ralph SJ
癌症治疗中使用细胞毒性药物的目的是选择性杀死并消除有害的癌细胞。如果它们以适当的方式死亡，细胞还可以释放危险信号，促进免疫反应，从而增强针对癌症的反应。这些免疫增强危险信号的身份、它们如何在细胞外和细胞内发挥作用，以及一些抗癌药物诱导细胞死亡以释放危险信号的分子机制是本次综述的主要焦点。一组特定的线粒体蛋白（维生素 E 类似物）通过靶向线粒体来驱动 ROS 产生，并促进更具免疫原性的癌细胞死亡方式，这就是此类抗癌药物的例证。讨论了活性氧 (ROS) 产生的作用以及导致死亡癌细胞线粒体诱导的炎症体和促炎介质激活的事件，以及它们对促进癌症免疫反应的证据。还评估了目前关于危险信号如何与免疫细胞相互作用以增强抗肿瘤反应的知识。
Cytotoxic drugs in cancer therapy are used with the expectation of selectively killing and thereby eliminating the offending cancer cells. If they should die in an appropriate manner, the cells can also release danger signals that promote an immune reaction that reinforces the response against the cancer. The identity of these immune-enhancing danger signals, how they work extra- and intracellularly, and the molecular mechanisms by which some anti-cancer drugs induce cell death to bring about the release of danger signals are the major focus of this review. A specific group of mitocans, the vitamin E analogs that act by targeting mitochondria to drive ROS production and also promote a more immunogenic means of cancer cell death exemplify such anti-cancer drugs. The role of reactive oxygen species (ROS) production and the events leading to the activation of the inflammasome and pro-inflammatory mediators induced by dying cancer cell mitochondria are discussed along with the evidence for their contribution to promoting immune responses against cancer. Current knowledge of how the danger signals interact with immune cells to boost the anti-tumor response is also evaluated.
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影响因子：
6.4
作者：
Cheuk, ATC;Mufti, GJ;Guinn, BA
通讯作者：
Guinn, BA
影响因子：
30.5
作者：
Buerckstuemmer, Tilmann;Baumann, Christoph;Superti-Furga, Giulio
通讯作者：
Superti-Furga, Giulio
影响因子：
4
作者：
Arnoult, Damien;Soares, Fraser;Girardin, Stephen E.
通讯作者：
Girardin, Stephen E.
影响因子：
2.7
作者：
Deaglio, S;Canella, D;Malavasi, F
通讯作者：
Malavasi, F
DOI：
10.1073/pnas.0909545106
发表时间：
2009-10-20
影响因子：
11.1
作者：
Choi, Myoung Kwon;Wang, ZhiChao;Taniguchi, Tadatsugu
通讯作者：
Taniguchi, Tadatsugu