Maternal nano-titanium dioxide inhalation alters fetoplacental outcomes in a sexually dimorphic manner.
Maternal nano-titanium dioxide inhalation alters fetoplacental outcomes in a sexually dimorphic manner.
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DOI：
10.3389/ftox.2023.1096173
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发表时间：
2023
影响因子：
--
通讯作者：
Nurkiewicz, Timothy R.
中科院分区：
文献类型：
--
作者：
Griffith, Julie A.;Dunn, Allison;DeVallance, Evan;Schafner, Kallie J.;Engles, Kevin J.;Batchelor, Thomas P.;Goldsmith, William T.;Wix, Kimberley;Hussain, Salik;Bowdridge, Elizabeth C.;Nurkiewicz, Timothy R.
胎盘在母体和胎儿循环之间的营养废物交换中起着至关重要的作用，因此作为一个界面，深刻影响胎儿的生长和发育。胎盘长期以来被认为是一种无性器官，但由于其胚胎起源，它与胎儿具有相同的性别。暴露于有毒物质（如柴油机废气）已被证明会导致性二态性结局，如暴露雌性的胎盘质量减少。因此，我们假设妊娠期间母体吸入纳米TiO 2会以性别二态的方式改变胎盘血流动力学。将妊娠第10-19天的Sprague-Dawley大鼠暴露于纳米TiO 2气溶胶（12.17 ± 1.69 mg/m3）或过滤空气（假对照）。在GD 20人道处死母鼠，并根据胎仔性别采集胎仔组织：整个胎盘、胎盘结合区（JZ）和胎盘迷路区（LZ）。评估胎儿质量、胎盘质量和胎盘区面积百分比的性别差异。暴露的雌性胎仔明显小于暴露的雄性胎仔（2.65 ± 0.03 g vs 2.78 ± 0.04 g）。与假手术对照组雌性相比，纳米TiO 2暴露组雌性胎仔的交界区面积百分比显著降低（24.37 ± 1.30% vs 30.39 ± 1.54%）。与假手术对照组雌性动物相比，纳米TiO 2雌性动物的迷路区面积百分比显著增加（75.63 ± 1.30% vs 69.61 ± 1.54%）。胎盘血流和血流动力学进行了评估与各种血管活性物质。研究发现，与假手术对照雌性胎仔（3.97 ± 1.30 mm Hg vs 9.10 ± 1.07 mm Hg）和纳米TiO 2雄性胎仔（9.96 ± 0.66 mm Hg）相比，暴露于纳米TiO 2的雌性胎仔在存在血栓烷（TXA 2）模拟物U46619的情况下仅流出压显著降低。母体纳米TiO 2吸入暴露对雌性胎儿质量、胎盘区质量和面积的影响更大，并对胎盘血管反应性产生不利影响。这可能会影响女性以后的生长发育，未来的研究需要进一步研究母体纳米TiO 2吸入暴露对区域特异性机制的影响。
The placenta plays a critical role in nutrient-waste exchange between the maternal and fetal circulations, thus functioning as an interface that profoundly impacts fetal growth and development. The placenta has long been considered an asexual organ, but, due to its embryonic origin it shares the same sex as the fetus. Exposures to toxicant such as diesel exhaust, have been shown to result in sexually dimorphic outcomes like decreased placental mass in exposed females. Therefore, we hypothesize that maternal nano-TiO2 inhalation exposure during gestation alters placental hemodynamics in a sexually dimorphic manner. Pregnant Sprague-Dawley rats were exposed from gestational day 10–19 to nano-TiO2 aerosols (12.17 ± 1.69 mg/m3) or filtered air (sham-control). Dams were euthanized on GD20, and fetal tissue was collected based on fetal sex: whole placentas, placental junctional zone (JZ), and placental labyrinth zone (LZ). Fetal mass, placental mass, and placental zone percent areas were assessed for sex-based differences. Exposed fetal females were significantly smaller compared to their exposed male counterparts (2.65 ± 0.03 g vs 2.78 ± 0.04 g). Nano-TiO2 exposed fetal females had a significantly decreased percent junctional zone area compared to the sham-control females (24.37 ± 1.30% vs 30.39 ± 1.54%). The percent labyrinth zone area was significantly increased for nano-TiO2 females compared to sham-control females (75.63 ± 1.30% vs 69.61 ± 1.54%). Placental flow and hemodynamics were assessed with a variety of vasoactive substances. It was found that nano-TiO2 exposed fetal females only had a significant decrease in outflow pressure in the presence of the thromboxane (TXA2) mimetic, U46619, compared to sham-control fetal females (3.97 ± 1.30 mm Hg vs 9.10 ± 1.07 mm Hg) and nano-TiO2 fetal males (9.96 ± 0.66 mm Hg). Maternal nano-TiO2 inhalation exposure has a greater effect on fetal female mass, placental zone mass and area, and adversely impacts placental vasoreactivity. This may influence the female growth and development later in life, future studies need to further study the impact of maternal nano-TiO2 inhalation exposure on zone specific mechanisms.
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DOI：
10.1186/s40348-018-0082-5
发表时间：
2018-03-20
期刊：
Molecular and cellular pediatrics
影响因子：
--
作者：
Menendez-Castro C;Rascher W;Hartner A
通讯作者：
Hartner A
影响因子：
5.5
作者：
Coan, P. M.;Vaughan, O. R.;Fowden, A. L.
通讯作者：
Fowden, A. L.
影响因子：
4.1
作者：
Nteeba, Jackson;Varberg, Kaela M.;Soares, Michael J.
通讯作者：
Soares, Michael J.
DOI：
10.1152/ajpheart.00634.2016
发表时间：
2017-03-01
影响因子：
4.8
作者：
Hathaway, Quincy A.;Nichols, Cody E.;Hollander, John M.
通讯作者：
Hollander, John M.
影响因子：
10
作者：
Kunovac, Amina;Hathaway, Quincy A.;Hollander, John M.
通讯作者：
Hollander, John M.