Dietary salt intake modulates angiotensin II type 1 receptor gene expression.
Dietary salt intake modulates angiotensin II type 1 receptor gene expression.
复制标题
膳食盐摄入量调节血管紧张素 II 1 型受体基因表达。
作者：
C. Schmid;H. Castrop;J. Reitbauer;R. Della Bruna;A. Kurtz
本研究的目的是表征饮食盐摄入对不同器官血管紧张素II 1型（AT 1）受体亚型基因表达的影响。给雄性Sprague-Dawley大鼠喂食低盐（0.2 mg/g）、正常盐（6 mg/g）或高盐（40 mg/g）饮食5、10和20天。在肾上腺、肾、肝和肺中测定两种AT 1受体亚型的mRNA水平。在所有的器官检查，除了肾上腺，低盐饮食导致AT 1A受体mRNA的丰度，但不是AT 1B mRNA，达到最低点之间的第5和第10天的喂养暂时减少。在肾上腺中，其中AT 1B受体占主导地位，低盐饮食导致该受体基因的表达短暂增加，在喂食的第10天左右达到最大值。高盐饮食对这些器官的AT 1受体基因表达无明显影响。这些研究结果表明，盐的摄入量，特别是减少盐的摄入量，显着影响AT 1受体基因表达的器官，时间和亚型依赖性的方式。似乎AT 1受体亚型受到低盐摄入的不同影响，在这种情况下，AT 1B受体基因表达增加，AT 1A受体基因表达减少。AT 1受体基因表达的这种差异反应可能与生物体能够适应口服盐摄入量减少有关。
This study aimed to characterize the influence of dietary salt intake on the gene expression of angiotensin II type 1 (AT1) receptor subtypes in different organs. Male Sprague-Dawley rats were fed low salt (0.2 mg/g), normal salt (6 mg/g), or high salt (40 mg/g) diets for 5, 10, and 20 days. mRNA levels for the two AT1 receptor subtypes were determined in adrenal gland, kidney, liver, and lung. In all of the organs examined, with the exception of the adrenal glands, low salt diet led to a transient decrease in the abundance of AT1A receptor mRNA but not of AT1B mRNA, which reached their nadirs between days 5 and 10 of feeding. In the adrenal gland, in which the AT1B receptor is predominant, low salt diet led to a transient increase in the expression of this receptor gene, with a maximum around day 10 of feeding. High salt diet exerted no significant influence on AT1 receptor gene expression in these organs. These findings indicate that the rate of salt intake, in particular, a reduction of salt intake, significantly influences AT1 receptor gene expression in an organ-, time-, and subtype-dependent fashion. It appears that AT1 receptor subtypes are differentially influenced by low salt intake, in that AT1B receptor gene expression increases and AT1A receptor gene expression decreases in this situation. This differential response of AT1 receptor gene expression may be relevant for the organism to be able to adapt to a reduction in oral salt intake.
低钠饮食对大鼠肾脏血管紧张素 II 受体亚型的差异调节。
DOI：
10.1161/01.hyp.25.4.872
发表时间：
1995
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Du,Y;Yao,A;Guo,D;Inagami,T;Wang,DH
通讯作者：
Wang,DH
影响因子：
--
作者：
BURSON, JM;AGUILERA, G;SIGMUND, CD
通讯作者：
SIGMUND, CD