Bio-inspired nanomedicine strategies for artificial blood components.
Bio-inspired nanomedicine strategies for artificial blood components.
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DOI：
10.1002/wnan.1464
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Sen Gupta A
中科院分区：
文献类型：
--
作者：
Sen Gupta A
血液是一种液体结缔组织，其中活细胞悬浮在非细胞液体基质中。血液的细胞成分提供气体交换（RBC）、免疫监视（WBC）和止血反应（血小板），而非细胞成分（盐、蛋白质等）提供血液的细胞成分提供血液的细胞成分。为身体的各种组织提供营养。这些血液成分的功能障碍和缺乏可导致显著的组织发病率和死亡率。因此，全血或其成分的输注是创伤、手术、骨髓抑制和先天性血液疾病管理的临床支柱。然而，供体来源的血液制品存在供应短缺、需要类型匹配、病原体污染的高风险、有限的便携性和保质期以及各种副作用的问题。虽然强有力的研究正致力于解决这些问题，但平行的临床兴趣已经发展到合成血液替代品的生物工程，其可以提供血液的功能，同时规避上述问题。纳米技术为实现这一目标提供了令人兴奋的方法，使用材料工程策略来创建合成和半合成RBC替代品以实现氧气运输，血小板替代品以实现止血和WBC替代品以实现细胞特异性免疫反应。这些方法中的一些进一步扩展了血细胞启发的合成和半合成构建体用于靶向药物递送和纳米医学的应用。目前的文章将提供一个全面的审查各种纳米技术的方法来设计合成血细胞，沿着的成功和挑战的关键讨论，目前的最先进的在这一领域。
Blood is a fluid connective tissue where living cells are suspended in non-cellular liquid matrix. The cellular components of blood render gas exchange (RBCs), immune surveillance (WBCs) and hemostatic responses (platelets), and the non-cellular components (salts, proteins etc.) provide nutrition to various tissues in the body. Dysfunction and deficiencies in these blood components can lead to significant tissue morbidity and mortality. Consequently, transfusion of whole blood or its components is a clinical mainstay in the management of trauma, surgery, myelosuppression and congenital blood disorders. However, donor-derived blood products suffer from issues of shortage in supply, need for type matching, high risks of pathogenic contamination, limited portability and shelf-life, and a variety of side-effects. While robust research is being directed to resolve these issues, a parallel clinical interest has developed towards bioengineering of synthetic blood substitutes that can provide blood’s functions while circumventing the above problems. Nanotechnology has provided exciting approaches to achieve this, using materials engineering strategies to create synthetic and semi-synthetic RBC substitutes for enabling oxygen transport, platelet substitutes for enabling hemostasis and WBC substitutes for enabling cell-specific immune response. Some of these approaches have further extended the application of blood cell-inspired synthetic and semi-synthetic constructs for targeted drug delivery and nanomedicine. The current article will provide a comprehensive review of the various nanotechnology approaches to design synthetic blood cells, along with a critical discussion of successes and challenges of the current state-of-art in this field.
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影响因子：
10.4
作者：
Blajchman, MA
通讯作者：
Blajchman, MA
影响因子：
17.1
作者：
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通讯作者：
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发表时间：
1992-02-01
影响因子：
5.5
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通讯作者：
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发表时间：
2008-10-01
影响因子：
3.2
作者：
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