Ascorbic acid: chemistry, biology and the treatment of cancer.
Ascorbic acid: chemistry, biology and the treatment of cancer.
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DOI：
10.1016/j.bbcan.2012.06.003
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发表时间：
2012-12
影响因子：
11.2
通讯作者：
Buettner, Garry R.
中科院分区：
文献类型：
--
作者：
Du, Juan;Cullen, Joseph J.;Buettner, Garry R.
自从维生素C被发现以来，其已知的生物学功能的数量不断扩大。抗坏血酸和维生素C这两个名字都反映了它的抗坏血病特性，因为它在结缔组织中胶原蛋白的合成中起作用。抗坏血酸盐作为电子供体，使铁保持在亚铁状态，从而保持胶原羟化酶的全部活性;与各种双加氧酶的平行反应影响多种基因的表达，例如通过HIF系统，以及通过细胞和组织的表观遗传景观。事实上，抗坏血酸盐的所有已知生理和生化功能都是由于其作为电子供体的作用。能够提供一个或两个电子使AscH-成为一种优秀的还原剂和抗氧化剂。抗坏血酸容易发生pH依赖性自氧化，产生过氧化氢（H2 O2）。在催化金属的存在下，这种氧化被加速。在这篇综述中，我们表明，抗坏血酸的化学和生物化学性质有助于其抗氧化剂以及其促氧化剂的性质。最近的药代动力学数据表明，静脉内（i. v.）抗坏血酸盐的给药绕过了对肠道的严格控制，产生高度升高的血浆水平;非常高水平的抗坏血酸盐可以作为前药向肿瘤递送显著通量的H2 O2。这一新的知识重新点燃了人们的兴趣，并刺激了对药理学抗坏血酸盐临床潜力的新研究。药理学抗坏血酸盐的作用机制的知识和理解为其用于治疗疾病，特别是静脉内递送药理学抗坏血酸盐作为癌症治疗中的佐剂的用途带来了理论基础。
Since the discovery of vitamin C, the number of its known biological functions is continually expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties due to its role in the synthesis of collagen in connective tissues. Ascorbate acts as an electron-donor keeping iron in the ferrous state thereby maintaining the full activity of collagen hydroxylases; parallel reactions with a variety of dioxygenases affect the expression of a wide array of genes, for example via the HIF system, as well as via the epigenetic landscape of cells and tissues. In fact, all known physiological and biochemical functions of ascorbate are due to its action as an electron donor. The ability to donate one or two electrons makes AscH− an excellent reducing agent and antioxidant. Ascorbate readily undergoes pH-dependent autoxidation producing hydrogen peroxide (H2O2). In the presence of catalytic metals this oxidation is accelerated. In this review, we show that the chemical and biochemical nature of ascorbate contribute to its antioxidant as well as its prooxidant properties. Recent pharmacokinetic data indicate that intravenous (i.v.) administration of ascorbate bypasses the tight control of the gut producing highly elevated plasma levels; ascorbate at very high levels can act as prodrug to deliver a significant flux of H2O2 to tumors. This new knowledge has rekindled interest and spurred new research into the clinical potential of pharmacological ascorbate. Knowledge and understanding of the mechanisms of action of pharmacological ascorbate bring a rationale to its use to treat disease especially the use of i.v. delivery of pharmacological ascorbate as an adjuvant in the treatment of cancer.
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影响因子：
3.9
作者：
BERGSTEN, P;YU, R;LEVINE, M
通讯作者：
LEVINE, M
影响因子：
3.5
作者：
Baader, SL;Bill, E;Matzanke, BF
通讯作者：
Matzanke, BF
阳离子Mn（III）N-取代的吡啶基卟啉的各种功能，被识别为SOD模拟物。
影响因子：
7.4
作者：
Batinic-Haberle I;Rajic Z;Tovmasyan A;Reboucas JS;Ye X;Leong KW;Dewhirst MW;Vujaskovic Z;Benov L;Spasojevic I
通讯作者：
Spasojevic I
影响因子：
7.4
作者：
BOYER, RF;MCCLEARY, CJ
通讯作者：
MCCLEARY, CJ
影响因子：
3.5
作者：
BENADE, L;HOWARD, T;BURK, D
通讯作者：
BURK, D