The ABC of Phytohormone Translocation.

The ABC of Phytohormone Translocation.
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DOI:
10.1055/s-0035-1545880
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发表时间:
2015-04
期刊:
影响因子:
2.7
通讯作者:
Ecker GF
Ecker GF
中科院分区:
医学3区
文献类型:
--
作者:
Hellsberg E;Montanari F;Ecker GF

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ATP驱动的跨生物膜转运是将溶质从细胞内部转运到细胞外环境的关键过程。在人类中,ATP结合盒转运蛋白参与吸收、分布、代谢、排泄和毒性,并且在抗癌药物耐药性中也起主要作用。类似的转运蛋白也被认为参与植物激素的转运。这些措施包括,例如,拟南芥中ABCB 1/19对生长素的转运,AtABCG 25对脱落酸的转运,以及矮牵牛ABC转运蛋白PDR 1对独脚金内酯的转运。在这篇文章中,我们概述了目前的知识,植物ABC转运蛋白的结构和功能,并提供,第一次,一个蛋白质同源性模型的独脚金内酯转运蛋白PDR 1从P.杂交。
ATP-driven transport across biological membranes is a key process to translocate solutes from the interior of the cell to the extracellular environment. In humans, ATP-binding cassette transporters are involved in absorption, distribution, metabolism, excretion, and toxicity, and also play a major role in anticancer drug resistance. Analogous transporters are also known to be involved in phytohormone translocation. These include, e.g., the transport of auxin by ABCB1/19 in Arabidopsis thaliana, the transport of abscisic acid by AtABCG25, and the transport of strigolactone by the Petunia hybrida ABC transporter PDR1. Within this article, we outline the current knowledge about plant ABC transporters with respect to their structure and function, and provide, for the first time, a protein homology model of the strigolactone transporter PDR1 from P. hybrida.
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