AtNIGT1/HRS1 integrates nitrate and phosphate signals at the Arabidopsis root tip.
AtNIGT1/HRS1 integrates nitrate and phosphate signals at the Arabidopsis root tip.
复制标题
DOI：
10.1038/ncomms7274
复制
发表时间：
2015-02-27
影响因子：
16.6
通讯作者：
Krouk, Gabriel
中科院分区：
文献类型：
--
作者：
Medici, Anna;Marshall-Colon, Amy;Ronzier, Elsa;Szponarski, Wojciech;Wang, Rongchen;Gojon, Alain;Crawford, Nigel M.;Ruffel, Sandrine;Coruzzi, Gloria M.;Krouk, Gabriel
氮和磷是世界上使用最广泛的肥料之一。硝酸盐（NO3−）和磷酸盐（PO 43 −）也是信号分子，其各自的转导途径正在被深入研究。然而，植物不断受到营养缺乏的挑战，但对这些信号通路如何整合知之甚少。在这里，我们报告了一个高度NO3-诱导NRT1.1控制的GARP转录因子，HRS 1的鉴定，记录其全基因组转录靶点，并验证其顺式调控元件。我们表明，这种转录因子和一个密切的同源物抑制主根生长在缺磷条件下，但只有当NO3-是存在的。该系统定义了一个集成P和N信号的分子逻辑门。我们认为NO3−和P信号通过同一蛋白HRS 1的双重转录和转录后控制而会聚
Nitrogen and phosphorus are among the most widely used fertilizers worldwide. Nitrate (NO3−) and phosphate (PO43−) are also signaling molecules whose respective transduction pathways are being intensively studied. However, plants are continuously challenged with combined nutritional deficiencies, yet very little is known about how these signaling pathways are integrated. Here we report the identification of a highly NO3−-inducible NRT1.1-controlled GARP transcription factor, HRS1, document its genome-wide transcriptional targets, and validate its cis-regulatory-elements. We demonstrate that this transcription factor and a close homolog repress primary root growth in response to P deficiency conditions, but only when NO3− is present. This system defines a molecular logic gate integrating P and N signals. We propose that NO3− and P signaling converge via double transcriptional and post-transcriptional control of the same protein, HRS1
登录
查看更多内容
影响因子：
7.4
作者：
Katari, Manpreet S.;Nowicki, Steve D.;Gutierrez, Rodrigo A.
通讯作者：
Gutierrez, Rodrigo A.
DOI：
10.1073/pnas.1316278111
发表时间：
2014-02-11
影响因子：
11.1
作者：
Franco-Zorrilla, Jose M.;Lopez-Vidriero, Irene;Solano, Roberto
通讯作者：
Solano, Roberto
影响因子：
9.9
作者：
通讯作者：
--
影响因子：
7.4
作者：
KHAMIS, S;LAMAZE, T;FOYER, C
通讯作者：
FOYER, C
影响因子：
64.8
作者：
Kerstetter, RA;Bollman, K;Poethig, RS
通讯作者：
Poethig, RS