Parasympathetic functioning and sleep problems in children with autism spectrum disorder.
Parasympathetic functioning and sleep problems in children with autism spectrum disorder.
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自闭症谱系障碍儿童的副交感神经功能与睡眠问题
DOI：
10.1002/aur.2816
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发表时间：
2022-11
期刊：
影响因子：
4.7
通讯作者：
Baker, Jason K.
中科院分区：
文献类型：
--
作者：
Schiltz, Hillary K.;Fenning, Rachel M.;Erath, Stephen A.;Baker, Jason K.
呼吸性窦性心律失常(RSA)是副交感神经系统活动的一个指标，在神经发育正常的儿童中与睡眠质量有关。目前的研究将这些过程的检查扩展到自闭症谱系障碍(ASD)儿童，这是一个有相当大睡眠问题风险的群体。参与者包括54名患有自闭症的儿童(年龄6-10岁 ，43%为西班牙裔)。RSA数据是通过有线MindWare系统在3分钟基线和3分钟质询任务期间收集的。父母使用儿童睡眠习惯问卷报告了他们孩子的睡眠问题和睡眠持续时间。尽管RSA指数与父母报告的儿童睡眠之间没有显著的相关性，但基线RSA和RSA反应性在预测睡眠问题方面存在交互作用。对于RSA反应性较高的儿童，基线RSA较高与较少的睡眠问题相关，但对于RSA反应性较低的儿童，基线RSA不能预测。RSA预测的睡眠持续时间没有主效应或交互作用。研究结果表明，患有ASD的儿童对睡眠问题的韧性表现出较高的基线RSA和较高的RSA反应性。这些结果的意义在于直接针对心理生理学(即副交感神经系统调节)作为改善ASD儿童睡眠的可能机制，并基于风险和弹性的生理标记物开发个性化干预措施。患有自闭症谱系障碍(ASD)的儿童通常睡眠困难，但其影响因素尚不清楚。研究结果表明，某些心理生理学倾向被认为代表了更好的整体唤醒调节和对挑战的更大生理反应，可能会保护自闭症儿童免受睡眠困难的影响。暗示强调了将心理生理调节作为减少睡眠问题的途径的潜力。
Respiratory sinus arrhythmia (RSA), an index of parasympathetic nervous system activity, has been linked with sleep quality among children with neurotypical development. The current study extended examination of these processes to children with autism spectrum disorder (ASD), a group at considerable risk for sleep problems. Participants included 54 children with ASD (aged 6–10 years, 43% Hispanic). RSA data were collected via a wired MindWare system during a 3‐min baseline and a 3‐min challenge task. Parents reported on their children's sleep problems and sleep duration using the Children's Sleep Habits Questionnaire, Abbreviated. Although no significant correlations emerged between RSA indices and parent‐reported child sleep, baseline RSA and RSA reactivity interacted in the prediction of sleep problems. For children with higher RSA reactivity, higher baseline RSA was associated with fewer sleep problems, but for children with lower RSA reactivity, baseline RSA was not predictive. No main effects or interactions of RSA predicted sleep duration. Findings suggest resilience against sleep problems for children with ASD presenting with higher baseline RSA and higher RSA reactivity. Implications of these results center upon directly targeting psychophysiology (i.e., parasympathetic nervous system regulation) as a possible mechanism to improve sleep in children with ASD, and developing personalized interventions based on physiological markers of risk and resilience. Children with autism spectrum disorder (ASD) often have difficulty sleeping, but contributing factors are not well understood. Findings suggest that certain psychophysiological tendencies thought to represent better overall arousal regulation and greater physiological reactivity to challenge may protect against sleep difficulties in children with ASD. Implications highlight the potential for targeting psychophysiological regulation as an avenue for reducing sleep problems.
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DOI：
10.1097/dbp.0000000000000595
发表时间：
2018
期刊：
Journal of developmental and behavioral pediatrics : JDBP
影响因子：
--
作者：
Coto J;Garcia A;Hart KC;Graziano PA
通讯作者：
Graziano PA
影响因子：
6.6
作者：
Burt, Keith B.;Obradovic, Jelena
通讯作者：
Obradovic, Jelena
影响因子：
3
作者：
Brezis, Rachel S.;Levin, Amitai;Levit-Binnun, Nava
通讯作者：
Levit-Binnun, Nava
影响因子：
2.1
作者：
Erath, Stephen A.;Bub, Kristen L.;Tu, Kelly M.
通讯作者：
Tu, Kelly M.
影响因子：
4.7
作者：
Barbier A;Chen JH;Huizinga JD
通讯作者：
Huizinga JD