Autism Spectrum Disorder in Children Is Not Associated With Abnormal Autonomic Nervous System Function: Hypothesis and Theory.
Autism Spectrum Disorder in Children Is Not Associated With Abnormal Autonomic Nervous System Function: Hypothesis and Theory.
复制标题
DOI：
10.3389/fpsyt.2022.830234
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Huizinga JD
中科院分区：
文献类型：
--
作者：
Barbier A;Chen JH;Huizinga JD
对自闭症谱系障碍（ASD）病理生理学的探索已经导致大量文献旨在提供基于心率和心率变异性（HRV）的自主神经功能障碍的证据，特别是呼吸窦性心律失常（RSA），一种副交感神经功能的测量。基于HRV和皮肤电分析，许多研究认为自闭症与迷走神经退缩和交感神经过度激活有关。我们将论证，对数据的批判性分析导致自主神经系统功能障碍不是自闭症的主要特征的假设。大多数ASD患儿的副交感神经基线值正常，对社会刺激的自主神经反应正常。现有HRV和皮肤电数据不能得出交感神经系统过度兴奋的结论。在实验环境中，一小部分ASD儿童的RSA值相对较低，心率相对较高。数据表明，这可能与研究期间相对较高的焦虑水平有关，与便秘等合并症有关，或者与使用精神活性药物有关。许多研究将他们的数据解释为符合自主神经功能障碍作为自闭症特征的首选假设，与多迷走神经理论有关，但HRV的证据恰恰相反。HRV分析可以识别由于合并症而有自主神经功能障碍的ASD儿童。
The quest to understand the pathophysiology of autism spectrum disorder (ASD) has led to extensive literature that purports to provide evidence for autonomic dysfunction based on heart rate and heart rate variability (HRV), in particular respiratory sinus arrhythmia (RSA), a measure of parasympathetic functioning. Many studies conclude that autism is associated with vagal withdrawal and sympathetic hyperactivation based on HRV and electrodermal analyses. We will argue that a critical analysis of the data leads to the hypothesis that autonomic nervous system dysfunction is not a dominant feature of autism. Most children with ASD have normal parasympathetic baseline values and normal autonomic responses to social stimuli. The existing HRV and electrodermal data cannot lead to the conclusion of an over-excitation of the sympathetic nervous system. A small subgroup of ASD children in experimental settings has relatively low RSA values and relatively high heart rates. The data suggest that this is likely associated with a relatively high level of anxiety during study conditions, associated with co-morbidities such as constipation, or due to the use of psychoactive medication. Many studies interpret their data to conform with a preferred hypothesis of autonomic dysfunction as a trait of autism, related to the polyvagal theory, but the HRV evidence is to the contrary. HRV analysis may identify children with ASD having autonomic dysfunction due to co-morbidities.
登录
查看更多内容
焦虑症与心率变异性降低有关：荟萃分析。
影响因子：
4.7
作者：
Chalmers JA;Quintana DS;Abbott MJ;Kemp AH
通讯作者：
Kemp AH
影响因子：
2.1
作者：
Bujnakova, I.;Ondrejka, I.;Tonhajzerova, I.
通讯作者：
Tonhajzerova, I.
影响因子：
5.2
作者：
Gillott, A;Furniss, F;Walter, A
通讯作者：
Walter, A
DOI：
10.1002/aur.1982
发表时间：
2019-01
期刊：
Autism research : official journal of the International Society for Autism Research
影响因子：
--
作者：
Bazelmans T;Jones EJH;Ghods S;Corrigan S;Toth K;Charman T;Webb SJ
通讯作者：
Webb SJ
DOI：
10.1016/j.autneu.2018.07.001
发表时间：
2018-12
期刊：
Autonomic neuroscience : basic & clinical
影响因子：
--
作者：
Fu Q;Levine BD
通讯作者：
Levine BD