Comparative genotoxicity and cytotoxicity of four hexavalent chromium compounds in human bronchial cells.
Comparative genotoxicity and cytotoxicity of four hexavalent chromium compounds in human bronchial cells.
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DOI：
10.1021/tx900363j
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发表时间：
2010-02-15
影响因子：
4.1
通讯作者：
Wise, John Pierce, Sr.
中科院分区：
文献类型：
--
作者：
Wise, Sandra S.;Holmes, Amie L.;Qin, Qin;Xie, Hong;Katsifis, Spiros P.;Thompson, W. Douglas;Wise, John Pierce, Sr.
六价铬（Cr（VI））化合物是公认的人类肺部致癌物。溶解度在其致癌性中起着重要作用，颗粒状Cr（VI）化合物是最具致癌性的。流行病学和动物研究表明，铬酸锌是最有效的颗粒铬（六价）化合物，然而，很少有比较数据来支持这些观察结果。本研究的目的是比较铬酸锌与其他两种颗粒状Cr（VI）化合物（铬酸钡和铬酸铅）和一种可溶性Cr（VI）化合物（铬酸钠）的遗传毒性。铬酸钡和铬酸锌的致染色体断裂作用相似，但铬酸铅引起的损伤明显较小。通过γ-H2 A.X焦点形成测量的DNA损伤水平对于三种颗粒铬化合物是相似的。校正铬摄取差异后，我们发现铬酸锌和铬酸钡的细胞毒性最大，铬酸铅和铬酸钠的细胞毒性较小。铬酸锌的致染色体断裂作用比其他铬化合物强，而铬酸铅的致染色体断裂作用最弱。任何化合物对DNA双链断裂的诱导作用均无显著差异。总之，这些数据表明，铬酸锌与其他铬化合物致癌效力的差异不仅仅是由于铬离子吸收的差异，锌阳离子实际上可能在其致癌性中发挥重要作用。
Hexavalent chromium (Cr(VI)) compounds are well-established human lung carcinogens. Solubility plays an important role in their carcinogenicity with the particulate Cr(VI) compounds being the most carcinogenic. Epidemiology and animal studies suggest that zinc chromate is the most potent particulate Cr(VI) compound, however, there are few comparative data to support these observations. The purpose of this study was to compare the genotoxicity of zinc chromate with two other particulate Cr(VI) compounds, barium chromate and lead chromate, and one soluble Cr(VI) compound, sodium chromate. The clastogenic effects of barium chromate and zinc chromate were similar but lead chromate induced significantly less damage. The levels of DNA damage measured by gamma-H2A.X foci formation were similar for the three particulate chromium compounds. Corrected for chromium uptake differences, we found that zinc chromate and barium chromate were the most cytotoxic and lead chromate and sodium chromate were less cytotoxic. Zinc chromate was more clastogenic than all other chromium compounds and lead chromate was the least clastogenic. There was no significant difference between any of the compounds for the induction of DNA double strand breaks. All together, these data suggest that the difference in the carcinogenic potency of zinc chromate over the other chromium compounds is not due solely to a difference in chromium ion uptake and the zinc cation may in fact have an important role in its carcinogenicity.
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DOI：
10.1097/00043764-198001000-00008
发表时间：
1980-01-01
影响因子：
3.2
作者：
DALAGER, NA;MASON, TJ;PAYNE, WW
通讯作者：
PAYNE, WW
影响因子：
3.8
作者：
Holmes, AL;Wise, SS;Wise, JP
通讯作者：
Wise, JP
影响因子：
3.9
作者：
Sliwinski, Tomasz;Czechowska, Agnieszka;Blasiak, Janusz
通讯作者：
Blasiak, Janusz
影响因子：
10.4
作者：
Klein CB;Su L;Bowser D;Leszczynska J
通讯作者：
Leszczynska J
影响因子：
3.8
作者：
Beaver LM;Stemmy EJ;Constant SL;Schwartz A;Little LG;Gigley JP;Chun G;Sugden KD;Ceryak SM;Patierno SR
通讯作者：
Patierno SR