Successful treatment of small cell variant anaplastic large cell lymphoma with allogeneic peripheral blood stem cell transplantation, and review of the literature
Successful treatment of small cell variant anaplastic large cell lymphoma with allogeneic peripheral blood stem cell transplantation, and review of the literature
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异基因外周血干细胞移植成功治疗小细胞变异型间变性大细胞淋巴瘤并文献复习
DOI：
10.1007/s12185-012-1242-3
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发表时间：
2013
期刊：
影响因子：
2.1
通讯作者：
Okamura T
中科院分区：
文献类型：
--
作者：
Imamura R;Mouri F;Oku E;Okamura T
间变性大细胞淋巴瘤（ALCL）的小细胞变体的表现方式与更常见的ALK+原发性ALCL几乎相同，不同之处在于它更常与白血病受累相关，并且据报告预后较差。我们报告一例40岁日本男性，诊断为小细胞变异型ALCL伴外周血受累IVB期，年龄校正国际预后指数3。骨髓穿刺标本的常规细胞遗传学显示异常中期分裂相，核型如下：47，XY，+X，t（2;5）（p23;q35）。患者接受了以急性淋巴细胞白血病为导向的强化化疗。他接受了HLA-DR 1位点不匹配的姐姐的异基因外周血干细胞移植。移植前，患者有残留淋巴结病，认为部分缓解。截至2012年8月，患者已实现18个月的持续完全缓解（CCR），Karnofsky评分为100%。我们在文献中共发现了7例接受异基因造血干细胞移植（HSCT）治疗的小细胞变异型ALCL病例。其中，没有报告复发，4名患者的CCR超过1年。同种异体HSCT似乎是小细胞变异型ALCL的一种有前景的治疗选择。
The small cell variant of anaplastic large cell lymphoma (ALCL) presents in a nearly identical manner to the more common ALK+primary ALCL, with the exception that it is more frequently associated with leukemic involvement, and the prognosis has been reported to be poor. We report a 40-year-old Japanese male who was diagnosed with small cell variant ALCL with peripheral blood involvement stage IVB, age-adjusted international prognostic index 3. Conventional cytogenetics of the bone marrow aspirate specimen showed abnormal metaphases with the following karyotype: 47, XY, +X, t(2;5)(p23;q35). The patient was treated with acute lymphoblastic leukemia-oriented intensive chemotherapy. He underwent allogeneic peripheral blood stem cell transplantation from his HLA-DR1 locus mismatch sister. Prior to transplant, the patient had residual lymphadenopathy considered to be in partial remission. As of August 2012, the patient has achieved 18 months of continuous complete remission (CCR), with a Karnofsky score of 100 %. We have identified a total of seven cases of small cell variant ALCL treated with allogeneic hematopoietic stem cell transplantation (HSCT) in the literature. Of these, no relapse was reported, and four patients were CCR more than 1 year. Allogeneic HSCT appears to represent a promising treatment option for small cell variant ALCL.
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DOI：
--
发表时间：
2004
期刊：
影响因子：
--
作者：
Yi;H. Wong;Y. Yeh;Chang Gung
通讯作者：
Chang Gung
影响因子：
11.4
作者：
Dodero, A.;Spina, F.;Corradini, P.
通讯作者：
Corradini, P.
影响因子：
4.3
作者：
Shigematsu, Akio;Kondo, Takeshi;Imamura, Masahiro
通讯作者：
Imamura, Masahiro
间变性大细胞淋巴瘤的小细胞变体。
影响因子：
4.6
作者：
T. Summers;J. Moncur
通讯作者：
J. Moncur
影响因子：
45.3
作者：
Le Gouill, Steven;Milpied, Noel;Michallet, Mauricette
通讯作者：
Michallet, Mauricette