Low viscoelastic clot strength, platelet transfusions, and graft dysfunction are associated with persistent postoperative ascites following liver transplantation.
Low viscoelastic clot strength, platelet transfusions, and graft dysfunction are associated with persistent postoperative ascites following liver transplantation.
复制标题
DOI：
10.1016/j.amjsurg.2022.09.054
复制
发表时间：
2022-12
影响因子：
3
通讯作者：
Moore, Hunter B.
中科院分区：
文献类型：
--
作者：
Jiang, Jessie G.;Ferrell, Tanner;Sauaia, Angela;Rodriguez, Ivan E.;Yoeli, Dor;Nydam, Trevor L.;Kennealey, Peter T.;Pomposelli, James J.;Pomfret, Elizabeth A.;Moore, Hunter B.
高输出量、持续性腹水（PA）是肝移植（LT）后常见的并发症。最近的工作已经确定，血小板有助于维持内皮完整性，并可以减少病理状态下的渗漏。我们试图评估LT后PA与血小板计数和血小板功能的关系。凝块强度（MA）是血小板功能的量度，并使用血栓弹性描记术（TEG）进行定量。在与TEG相同的时间范围内，以24小时间隔记录术后总引流量。在P0D7，PA被认为> 1L，因为如此多的输出阻止了排水去除。前瞻性入组了105例术前有中量或大量腹水的LT受者。PA发生率为28%。除POD5 TEG MA和POD5 MELD评分外，手术前后血小板输注与PA相关。PA患者住院时间较长，腹腔内感染率增加。肝移植后持续性腹水相对常见，并与血小板输注、低凝块强度和移植物功能障碍有关。
High output, persistent ascites (PA) is a common complication following liver transplant (LT). Recent work has identified that platelets help maintain endothelial integrity and can decrease leakage in pathological states. We sought to assess the association of PA following LT with platelet count and platelet function. Clot strength (MA) is a measure of platelet function and was quantified using thrombelastography (TEG). Total drain output following surgery was recorded in 24-h intervals during the same time frame as TEG. PA was considered >1 L on POD7, as that much output prohibits drain removal. 105 LT recipients with moderate or high volume preoperative ascites were prospectively enrolled. PA occurred in 28%. Platelet transfusions before and after surgery were associated with PA, in addition to POD5 TEG MA and POD5 MELD score. Patients with PA had a longer hospital length of stay and an increased rate of intraabdominal infections. Persistent ascites following liver transplant is relatively common and associated with platelet transfusions, low clot strength, and graft dysfunction.
登录
查看更多内容
影响因子：
25.7
作者：
MCCAUGHAN, GW;HERKES, R;SHEIL, AGR
通讯作者：
SHEIL, AGR
影响因子：
6.2
作者：
Schiefer, Judith;Lebherz-Eichinger, Diana;Faybik, Peter
通讯作者：
Faybik, Peter
影响因子：
2.6
作者：
Kim, Joohyun;Yi, Nam-Joon;Suh, Kyung-Suk
通讯作者：
Suh, Kyung-Suk
影响因子：
4.6
作者：
Lesurtel, Mickael;Raptis, Dimitri A.;Clavien, Pierre-Alain
通讯作者：
Clavien, Pierre-Alain
影响因子：
3.1
作者：
Deng, Xiyun;Cao, Yanna;Ko, Tien C.
通讯作者：
Ko, Tien C.