Sensing cellular stress through STIM proteins.

Sensing cellular stress through STIM proteins.
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DOI:
10.1038/nchembio.619
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发表时间:
2011-07-18
影响因子:
14.8
通讯作者:
Gill, Donald L.
Gill, Donald L.
中科院分区:
生物学1区
文献类型:
--
作者:
Soboloff, Jonathan;Madesh, Muniswamy;Gill, Donald L.

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为了响应内质网中 Ca2+ 水平的降低,STIM 蛋白与质膜中的 Orai 通道偶联,导致 Ca2+ 流入细胞。除了 Ca2+ 相关的内质网应激之外,STIM 蛋白也正在作为通用应激传感器出现,它对多种应激信号做出反应,以协调 Ca2+ 信号传导和体内平衡。
In response to decreasing Ca2+ levels in the endoplasmic reticulum, STIM proteins couple with Orai channels in the plasma membrane, leading to Ca2+ influx into the cell. In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis.
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