Roles of mechanosensitive ion channels in immune cells.
Roles of mechanosensitive ion channels in immune cells.
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DOI：
10.1016/j.heliyon.2023.e23318
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发表时间：
2024-01-15
期刊：
影响因子：
4
通讯作者：
Jia, Hao
中科院分区：
文献类型：
--
作者：
Xia, Kexin;Chen, Xiaolin;Wang, Wenyan;Liu, Qianwen;Zhao, Mai;Ma, Jiacheng;Jia, Hao
机械敏感性离子通道是一类膜整合蛋白，其将外部机械力（包括拉伸、压力、重力和渗透压变化，其中一些可以由病原体入侵引起）转化为传递到细胞质的电信号和化学信号。近年来，随着这些通道的发现，它们在许多疾病的发生和发展中的作用逐渐被揭示出来。多项研究表明，机械敏感性离子通道通过在免疫细胞表面表达并进一步响应机械力来调节免疫细胞的增殖、活化和炎症反应。尽管如此，需要进一步澄清有关免疫细胞模式识别受体的信号转导途径，以及微环境变化和机械力对免疫细胞的影响。本文综述了机械敏感性离子通道在免疫细胞中的作用。
Mechanosensitive ion channels are a class of membrane-integrated proteins that convert externalmechanical forces, including stretching, pressure, gravity, and osmotic pressure changes, some of which can be caused by pathogen invasion, into electrical and chemical signals transmitted to the cytoplasm. In recent years, with the identification of many of these channels, their roles in the initiation and progression of many diseases have been gradually revealed. Multiple studies have shown that mechanosensitive ion channels regulate the proliferation, activation, and inflammatory responses of immune cells by being expressed on the surface of immune cells and further responding to mechanical forces. Nonetheless, further clarification is required regarding the signaling pathways of immune-cell pattern-recognition receptors and on the impact of microenvironmental changes and mechanical forces on immune cells. This review summarizes the roles of mechanosensitive ion channels in immune cells.
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