The response to stressors in adulthood depends on the interaction between prenatal exposure to glucocorticoids and environmental context.
The response to stressors in adulthood depends on the interaction between prenatal exposure to glucocorticoids and environmental context.
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DOI：
10.1038/s41598-023-33447-x
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发表时间：
2023-04-15
影响因子：
4.6
通讯作者：
Haussmann, Mark F.
中科院分区：
文献类型：
--
作者：
Majer, Ariana D.;Paitz, Ryan T.;Tricola, Gianna M.;Geduldig, Jack E.;Litwa, Hannah P.;Farmer, Jenna L.;Prevelige, Brenna R.;McMahon, Elyse K.;McNeely, Taylor;Sisson, Zach R.;Frenz, Brian J.;Ziur, Alexis D.;Clay, Emily J.;Eames, Brad D.;McCollum, Shannon E.;Haussmann, Mark F.
生育期间的母体压力可能会影响后代在以后的生活中对压力的反应。终生暴露在压力下释放的糖皮质激素与行为障碍、疾病易感性和死亡率的风险更大有关。个体应激反应的巨大差异部分是由产前接触糖皮质激素造成的。为了探索胚胎糖皮质激素暴露的长期影响，我们向日本鹌鹑(Coturnix Japan Onica)的卵注射皮质酮。我们描述了后代的内分泌应激反应，并测量了三个不同年龄段的攻击体验。我们发现，产前接触糖皮质激素影响(1)应激反应终止的速度，表明负反馈失调，(2)基线皮质酮水平取决于当前环境条件，与更高水平的基线皮质酮相关的更高水平的有经验的攻击，(3)基于基线浓度的急性应激反应的幅度。最后，我们提出了一个框架，可以用来在未来的工作中测试这些发现。总体而言，我们的发现表明，产前接触糖皮质激素的潜在适应性可能取决于环境背景，也可能被每次动物面临应激源时长期接触糖皮质激素的负面影响所缓和。
Maternal stress during reproduction can influence how offspring respond to stress later in life. Greater lifetime exposure to glucocorticoid hormones released during stress is linked to greater risks of behavioral disorders, disease susceptibility, and mortality. The immense variation in individual’s stress responses is explained, in part, by prenatal glucocorticoid exposure. To explore the long-term effects of embryonic glucocorticoid exposure, we injected Japanese quail (Coturnix japonica) eggs with corticosterone. We characterized the endocrine stress response in offspring and measured experienced aggression at three different ages. We found that prenatal glucocorticoid exposure affected (1) the speed at which the stress response was terminated suggesting dysregulated negative feedback, (2) baseline corticosterone levels in a manner dependent on current environmental conditions with higher levels of experienced aggression associated with higher levels of baseline corticosterone, (3) the magnitude of an acute stress response based on baseline concentrations. We finish by proposing a framework that can be used to test these findings in future work. Overall, our findings suggest that the potential adaptive nature of prenatal glucocorticoid exposure is likely dependent on environmental context and may also be tempered by the negative effects of longer exposure to glucocorticoids each time an animal faces a stressor.
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影响因子：
2
作者：
HAMILTON, WD
通讯作者：
HAMILTON, WD
影响因子：
1.6
作者：
Angelier, Frederic;Shaffer, Scott A.;Chastel, Olivier
通讯作者：
Chastel, Olivier
影响因子：
64.8
作者：
Bateson, P;Barker, D;Sultan, SE
通讯作者：
Sultan, SE
影响因子：
2.2
作者：
Haussmann, Mark F.;Marchetto, Nicole M.
通讯作者：
Marchetto, Nicole M.
DOI：
10.1093/gerona/glu055
发表时间：
2014-06-01
影响因子：
5.1
作者：
Epel, Elissa S.;Lithgow, Gordon J.
通讯作者：
Lithgow, Gordon J.