Infant weight-for-length gain associated with autonomic nervous system reactivity.
Infant weight-for-length gain associated with autonomic nervous system reactivity.
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DOI：
10.1038/s41390-020-01246-z
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发表时间：
2021-08
影响因子：
3.6
通讯作者：
Bush NR
中科院分区：
文献类型：
--
作者：
Rudd KL;Alkon A;Abrams B;Bush NR
研究表明，儿童的健康和幸福是由核心适应系统支持的，包括自主神经系统（ANS）。尽管有证据表明成年ANS调节在疾病发展中的重要性，但很少有研究调查早期发育如何影响新出现的ANS功能。因此，我们研究了婴儿早期肥胖增加与6个月时ANS调节的关系。从出生记录中提取婴儿体重和身高，并在6个月的评估期间测量一个低收入、种族/民族多样化的样本（N = 60）。在世卫组织标准化体重长增比变化中计算了生命的前6个月。在发育挑战性的静止面孔范式（SFP）中，通过交感神经系统（即射血前期）和副交感神经系统（即呼吸性窦性心律失常）的联合反应来测量ANS反应性。ANS的“经典反应性”反应的特征是交感神经激活和副交感神经退缩。前6个月较低的体重增长预示着静止面部的典型反应。然而，体重比身高增加的幅度越大，预示着团聚期间婴儿会出现“经典反应”，此时婴儿有望康复，这表明自主神经失调。这些发现表明，生命早期肥胖增加与婴儿ANS调节的发展之间存在关联。
Research suggests that children’s health and well-being are supported by core adaptive systems, including the autonomic nervous system (ANS). Despite evidence for the importance of adulthood ANS regulation in the development of disease, few studies have examined how early development may influence emerging ANS function. Therefore, we examined how infant adiposity gain during early infancy related to ANS regulation at 6-months. Infant weight and length were abstracted from birth records and measured during the 6-month assessment in a low-income, racially/ethnically diverse sample (N = 60). WHO-standardized weight-for-length-gain change was calculated across the first 6 months of life. ANS reactivity was measured as the combined sympathetic (i.e., pre-ejection period) and parasympathetic (i.e., respiratory sinus arrhythmia) nervous system responses during the developmentally challenging Still Face Paradigm (SFP). ANS “classic reactivity” response was characterized by paired sympathetic activation and parasympathetic withdrawal. Lower weight-for-length gain in the first 6 months predicted classic reactivity during still face. However, greater weight-for-length gain predicted ‘classic reactivity’ during the reunion, when infants were expected to recover, suggesting autonomic dysregulation. These findings suggest an association between early life adiposity gain and the development of infant ANS regulation.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
3.7
作者：
Berntson, GG;Lozano, DL;Cacioppo, JT
通讯作者：
Cacioppo, JT
影响因子：
3.3
作者：
McCorry, Laurie Kelly
通讯作者：
McCorry, Laurie Kelly
DOI：
10.1097/dbp.0b013e3182331fa6
发表时间：
2011-11-01
影响因子：
2.4
作者：
Alkon, Abbey;Boyce, W. Thomas;Eskenazi, Brenda
通讯作者：
Eskenazi, Brenda
影响因子：
5.8
作者：
Pearson, SR;Alkon, A;Boyce, WT
通讯作者：
Boyce, WT