The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment.
The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment.
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环状核苷酸信号通路在癌症中的作用：预防和治疗的靶标。
DOI：
10.3390/cancers6010436
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发表时间：
2014-02-26
期刊：
影响因子：
5.2
通讯作者：
Tinsley HN
中科院分区：
文献类型：
--
作者：
Fajardo AM;Piazza GA;Tinsley HN
四十多年来，环核苷酸环腺苷酸（cAMP）和环鸟苷酸（cGMP）已被认为是细胞内重要的信号分子。在正常生理条件下，环核苷酸调节无数生物过程，如细胞生长和粘附、能量稳态、神经元信号传导和肌肉松弛。此外，已在许多病理生理条件（包括癌症）中观察到改变的环核苷酸信号传导。虽然负责这些影响的不同分子改变取决于特定的癌症类型，但一些研究已经证明，通过三种机制之一来激活环核苷酸信号传导-诱导环核苷酸合成，抑制环核苷酸降解或激活环核苷酸受体-足以抑制许多类型的癌细胞的增殖并激活凋亡。这些发现表明，靶向环核苷酸信号传导可以为发现用于预防和/或治疗选定癌症的新型药物提供策略。
For more than four decades, the cyclic nucleotides cyclic AMP (cAMP) and cyclic GMP (cGMP) have been recognized as important signaling molecules within cells. Under normal physiological conditions, cyclic nucleotides regulate a myriad of biological processes such as cell growth and adhesion, energy homeostasis, neuronal signaling, and muscle relaxation. In addition, altered cyclic nucleotide signaling has been observed in a number of pathophysiological conditions, including cancer. While the distinct molecular alterations responsible for these effects vary depending on the specific cancer type, several studies have demonstrated that activation of cyclic nucleotide signaling through one of three mechanisms—induction of cyclic nucleotide synthesis, inhibition of cyclic nucleotide degradation, or activation of cyclic nucleotide receptors—is sufficient to inhibit proliferation and activate apoptosis in many types of cancer cells. These findings suggest that targeting cyclic nucleotide signaling can provide a strategy for the discovery of novel agents for the prevention and/or treatment of selected cancers.
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影响因子：
7.5
作者：
Camici, Marcello
通讯作者：
Camici, Marcello
影响因子：
--
作者：
Ceyhan, Ozge;Birsoy, Kivanc;Hoffman, Charles S.
通讯作者：
Hoffman, Charles S.
DOI：
10.1038/sj.neo.7900039
发表时间：
1999-10-01
期刊：
Neoplasia (New York)
影响因子：
--
作者：
Carlson, Chris C.;Smithers, Stacy L.;Dransfield, Daniel T.
通讯作者：
Dransfield, Daniel T.
影响因子：
4.8
作者：
Chen, Hongjie;Levine, Yehoshua C.;Lin, Alison J.
通讯作者：
Lin, Alison J.
影响因子：
11.2
作者：
Cen, Bo;Deguchi, Atsuko;Weinstein, I. Bernard
通讯作者：
Weinstein, I. Bernard