Stereochemical Strategy Advances Microbially Antiadhesive Cotton Textile in Safeguarding Skin Flora.
Stereochemical Strategy Advances Microbially Antiadhesive Cotton Textile in Safeguarding Skin Flora.
复制标题
立体化学策略推进微生物抗粘连棉纺织品保护皮肤菌群（封面）
DOI：
10.1002/adhm.201900232
复制
发表时间：
2019-08
影响因子：
10
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Xu J;Zhao H;Xie Z;Ruppel S;Zhou X;Chen S;Liang JF;Wang X
棉纺织品（CT）上的微生物污染对人们的健康以及纺织品本身在使用和储存过程中产生负面影响。以身体安全的方式使用抗微生物CT目前仍然是一个挑战，因为很难平衡杀灭微生物和保护皮肤植物群。在此，我们报告了一种通过将β-4-甲酰苯甲酸分子偶联到氨基修饰的CT上而修饰的CT（BDCT）。该BDCT对革兰氏阳性菌（金黄色葡萄球菌和表皮葡萄球菌）、革兰氏阴性菌（大肠杆菌和铜绿假单胞菌）和真菌（尼日尔曲霉、总状毛霉和白色念珠菌）显示出强而广谱的微生物抗粘附活性。由于其独特的立体化学微生物防粘连机制，BDCT对皮肤植物群无害。此外，BDCT还具有显著的抗微生物粘附能力，耐50次加速洗涤。因此，这种立体化学BDCT策略在新一代纺织品、食品包装和医疗防护等方面显示出巨大的应用潜力。冰片装饰棉纺织品（BDCT）具有很强的抗微生物粘附性能和洗涤稳定性。它通过采用独特的立体化学策略实现了对微生物粘附的广谱抑制。因此，BDCT满足了功能性CT的前沿，这推动了抗菌CT的发展，以保护我们免受潜在有害微生物的侵害，并且不会损害皮肤植物群。
Microbial contamination on cotton textiles (CT) negatively affects people’s health as well as the textile itself during use and storage. Using antimicrobial CT in a body safe manner is currently still a challenge because it is difficult to balance killing microbes and protecting skin flora. Herein, we report a borneol-decorated CT (BDCT) through coupling of borneol 4-formylbenzoate molecules onto the amino-modified CT. This BDCT shows strong and broad-spectrum microbially anti-adhesive activities against gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and fungi (Aspergillus niger, Mucor racemosus and Candida albicans). Because of its unique stereochemical microbial anti-adhesion mechanism, BDCT is harmless to skin flora. In addition, BDCT exhibits prominent durability of microbially anti-adhesive capability by bearing 50 times of accelerated laundering. Therefore, this stereochemical BDCT strategy shows great potential for applications in the new generation of textiles, food packaging and medical protection. Borneol-decorated cotton textile (BDCT) with strong microbially anti-adhesive properties and laundering stability is present. It achieves broad-spectrum inhibition of microbial adhesion through employing the unique stereochemical strategy. BDCT is thus meeting the frontier of functional CT, which advances antimicrobial CT to protect us from potentially harmful microorganisms and do no harm to skin flora.
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DOI：
10.1016/s1010-6030(03)00103-5
发表时间：
2003-05-30
影响因子：
4.3
作者：
Latch, DE;Packer, JL;McNeill, K
通讯作者：
McNeill, K
DOI：
10.1073/pnas.1424409112
发表时间：
2015-04-28
影响因子：
11.1
作者：
Bouslimani, Amina;Porto, Carla;Dorrestein, Pieter C.
通讯作者：
Dorrestein, Pieter C.
影响因子：
11.2
作者：
Gao, Dangge;Li, Yajuan;Ma, Jianzhong
通讯作者：
Ma, Jianzhong
影响因子：
2.7
作者：
Hassan, Mahmoud S.;Ali, Hussein E.;Ali, Nisreen M.
通讯作者：
Ali, Nisreen M.
影响因子：
1.8
作者：
Ocepek, Barbara;Boh, Bojana;Tavcer, Petra Forte
通讯作者：
Tavcer, Petra Forte