Physiological and environmental control of yeast prions.
Physiological and environmental control of yeast prions.
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DOI：
10.1111/1574-6976.12053
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发表时间：
2014-03
影响因子：
11.3
通讯作者：
Chernoff YO
中科院分区：
文献类型：
--
作者：
Chernova TA;Wilkinson KD;Chernoff YO
朊病毒是一种自我延续的蛋白质亚型，在哺乳动物中引起致命和无法治愈的神经退行性疾病。最近的证据表明，大多数与淀粉样蛋白和神经包涵体疾病有关的人类蛋白质至少具有一些朊病毒特性。在酵母等低等真核生物中，朊病毒作为表观遗传因子，通过改变一系列细胞过程来增加表型多样性。虽然一些酵母朊病毒明显具有致病性，但也假设朊病毒的形成在可变的环境条件下可能是有益的。酵母和哺乳动物朊病毒具有相似的分子特性。在酵母模型中揭示了影响朊病毒形成和繁殖的关键细胞因素和条件。应激相关伴侣、蛋白质量控制沉积物、降解途径和细胞骨架网络控制着酵母中朊病毒的形成和繁殖。环境压力触发朊病毒的形成和丢失，据推测是通过影响细胞内朊病毒诱导蛋白的浓度，和/或通过外源辅助辅助物将朊病毒生成蛋白定位到朊病毒诱导位点来起作用的。酵母朊病毒的生理和环境调节为针对一般细胞系统的药物干预和/或预防措施提供了新的机会，而不是针对单个淀粉样蛋白和朊病毒的特性。
Prions are self-perpetuating protein isoforms that cause fatal and incurable neurodegenerative disease in mammals. Recent evidence indicates that a majority of human proteins involved in amyloid and neural inclusion disorders possess at least some prion properties. In lower eukaryotes, such as yeast, prions act as epigenetic elements, which increase phenotypic diversity by altering a range of cellular processes. While some yeast prions are clearly pathogenic, it is also postulated that prion formation could be beneficial in variable environmental conditions. Yeast and mammalian prions have similar molecular properties. Crucial cellular factors and conditions influencing prion formation and propagation were uncovered in the yeast models. Stress-related chaperones, protein quality control deposits, degradation pathways and cytoskeletal networks control prion formation and propagation in yeast. Environmental stresses trigger prion formation and loss, supposedly acting via influencing intracellular concentrations of the prion-inducing proteins, and/or by localizing prionogenic proteins to the prion induction sites via heterologous ancillary helpers. Physiological and environmental modulation of yeast prions points to new opportunities for pharmacological intervention and/or prophylactic measures targeting general cellular systems rather than the properties of individual amyloids and prions.
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影响因子：
4.8
作者：
Allen, Kim D.;Chernova, Tatiana A.;Chernoff, Yury O.
通讯作者：
Chernoff, Yury O.
影响因子：
2.6
作者：
CHERNOFF, YO;INGEVECHTOMOV, SG;TERAVANESYAN, MD
通讯作者：
TERAVANESYAN, MD
影响因子：
4.8
作者：
Chernova, TA;Allen, KD;Wilkinson, KD
通讯作者：
Wilkinson, KD
影响因子：
2.3
作者：
Andre, Ralph;Tabrizi, Sarah J.
通讯作者：
Tabrizi, Sarah J.
影响因子：
3.3
作者：
Allen, KD;Wegrzyn, RD;Chernoff, YO
通讯作者：
Chernoff, YO