Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease.
Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease.
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DOI：
10.1016/j.neurobiolaging.2017.07.006
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发表时间：
2017-11
影响因子：
4.2
通讯作者：
Raghanti MA
中科院分区：
文献类型：
--
作者：
Edler MK;Sherwood CC;Meindl RS;Hopkins WD;Ely JJ;Erwin JM;Mufson EJ;Hof PR;Raghanti MA
阿尔茨海默病（Alzheimer's disease，AD）是一种独特的人类脑部疾病，其特征在于淀粉样β蛋白（amyloid beta protein，Aβ）积聚到细胞外斑块中，由细胞内异常磷酸化的tau蛋白形成神经元缠结（neuroendocrine tangles，NFT），以及选择性神经元损失。我们分析了一大群老年黑猩猩（n = 20，年龄37-62岁），以寻找人类受AD影响的大脑区域中Aβ和tau病变的证据。在斑块和血管中观察到Aβ，并以pretangles、NFT和tau免疫反应性神经炎簇的形式发现tau病变。血管中的Aβ沉积高于斑块中的A β沉积，并且与tau病变的增加相关，这表明黑猩猩大脑微血管中的淀粉样蛋白积聚先于斑块形成。年龄与较大的Aβ斑块和血管体积相关。在表现出斑块和中度或重度脑淀粉样血管病的个体中观察到缠结病理学，淀粉样血管病是淀粉样蛋白在脑血管系统中积累的一种状况。老年黑猩猩的淀粉样蛋白和tau蛋白病理学表明这些AD病变并非人类大脑特有。
Alzheimer’s disease (AD) is a uniquely human brain disorder characterized by the accumulation of amyloid beta protein (Aβ) into extracellular plaques, neurofibrillary tangles (NFT) made from intracellular, abnormally phosphorylated tau, and selective neuronal loss. We analyzed a large group of aged chimpanzees (n = 20, ages 37–62 years) for evidence of Aβ and tau lesions in brain regions affected by AD in humans. Aβ was observed in plaques and blood vessels, and tau lesions were found in the form of pretangles, NFT, and tauimmunoreactive neuritic clusters. Aβ deposition was higher in vessels than in plaques and correlated with increases in tau lesions, suggesting that amyloid build-up in the brain’s microvasculature precedes plaque formation in chimpanzees. Age was correlated to greater volumes of Aβ plaques and vessels. Tangle pathology was observed in individuals that exhibited plaques and moderate or severe cerebral amyloid angiopathy, a condition in which amyloid accumulates in the brain’s vasculature. Amyloid and tau pathology in aged chimpanzees suggests these AD lesions are not specific to the human brain.
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DOI：
10.1046/j.1365-2818.2001.00958.x
发表时间：
2001-12-01
期刊：
JOURNAL OF MICROSCOPY-OXFORD
影响因子：
--
作者：
Dorph-Petersen, KA;Nyengaard, JR;Gundersen, HJG
通讯作者：
Gundersen, HJG
影响因子：
1.4
作者：
Anderson, US;Stoinski, TS;Maple, TL
通讯作者：
Maple, TL
影响因子：
3.3
作者：
Bussière, T;Gold, G;Hof, PR
通讯作者：
Hof, PR
影响因子：
6
作者：
Bussière, T;Bard, F;Buttini, M
通讯作者：
Buttini, M
影响因子：
2.4
作者：
DYKE, B;GAGE, TB;WILLIAMSBLANGERO, S
通讯作者：
WILLIAMSBLANGERO, S