Breaking New Ground: The Crucial Role of Animal Research in the Advancement of Rhabdomyolysis-Induced AKI Treatment and Prevention.
Breaking New Ground: The Crucial Role of Animal Research in the Advancement of Rhabdomyolysis-Induced AKI Treatment and Prevention.
复制标题
开辟新天地：动物研究在横纹肌溶解诱导的急性肾损伤治疗和预防进展中的关键作用
DOI：
10.1093/function/zqad039
复制
发表时间：
2023
期刊：
影响因子：
6.2
通讯作者：
Palygin, Oleg
中科院分区：
文献类型：
--
作者：
Semenikhina, Marharyta;Lipschutz, Joshua H.;Palygin, Oleg
受损肌肉组织的分解导致各种物质的释放，包括肌红蛋白，钾，肌酸激酶和乳酸，进入血液。不幸的是，这可能导致急性肾损伤（阿基），这是死亡率、慢性肾病（CKD）和终末期肾病（ESKD）的主要风险因素。这种危险的情况被称为横纹肌溶解引起的急性肾损伤（RIAKI），是急性骨骼肌破坏的常见并发症，影响13%至50%的患者。横纹肌溶解症可以由一系列因素单独或联合引起，例如创伤，长期固定，剧烈体力活动，某些药物，感染，甚至遗传性或获得性代谢性肌病。从历史上看，横纹肌溶解症症状的详细报告及其肾脏并发症的理解出现在第一次世界大战和第二次世界大战期间的大量战斗伤亡人员中，当时RIAKI的基本机制和肌红蛋白尿对肾功能的有害影响被确立。2自那时以来，RIAKI一直是民用灾害和军事医学的一个重要课题，并继续是一个具有挑战性的问题，导致发病率和死亡率。3
The breakdown of damaged muscle tissues leads to the release of various substances, including myoglobin, potassium, creatine kinase, and lactic acid, into the bloodstream. Unfortunately, this can result in acute kidney injury (AKI), which is a major risk factor for mortality, chronic kidney disease (CKD), and end-stage kidney disease (ESKD). This dangerous condition, known as rhabdomyolysis-induced acute kidney injury (RIAKI), is a common complication of acute skeletal muscle destruction, affecting anywhere from 13% to 50% of patients. 1 Rhabdomyolysis can be caused by a range of factors, either on their own or in combination, such as trauma, prolonged immobilization, intense physical activity, certain medications, infections, and even hereditary or acquired metabolic myopathies. Historically, detailed reports of rhabdomyolysis symptoms and the understanding of its renal complications emerged from a large cohort of combat casualties during World Wars I and II, when the basic mechanisms of RIAKI and harmful impacts of myoglobinuria on kidney function were established. 2 Since then, RIAKI has remained an important topic in civilian disasters and military medicine and continues to be a challenging issue contributing to morbidity and mortality. 3
登录
查看更多内容
影响因子：
56.9
作者：
HALLER, RG;DRACHMAN, DB
通讯作者：
DRACHMAN, DB
影响因子：
6.2
作者：
Afolabi, Jeremiah M.;Kanthakumar, Praghalathan;Williams, Jada D.;Kumar, Ravi;Soni, Hitesh;Adebiyi, Adebowale
通讯作者：
Adebiyi, Adebowale
影响因子：
120.7
作者：
MAYS, ET;CHRISTOPHERSON, WM;WILLIAMS, HC
通讯作者：
WILLIAMS, HC
影响因子：
6.1
作者：
Salahudeen, AK;Wang, CY;Tachikawa, H
通讯作者：
Tachikawa, H
影响因子：
3.5
作者：
Watanabe, Katsuhito;Oda, Shingo;Yokoi, Tsuyoshi
通讯作者：
Yokoi, Tsuyoshi