Impact of body size and body composition on bladder cancer outcomes: Risk stratification and opportunity for novel interventions.
Impact of body size and body composition on bladder cancer outcomes: Risk stratification and opportunity for novel interventions.
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DOI：
10.1016/j.urolonc.2020.03.017
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Furberg H
中科院分区：
文献类型：
--
作者：
Sanchez A;Kissel S;Coletta A;Scott J;Furberg H
在膀胱癌的研究中，体型是一个新的和临床相关的患者因素。从历史上看，患者的身体质量指数（BMI）一直被用作肥胖的代表，但它与患病风险以及大多数临床结果的关联并不一致。更具体的身体组成特征可以通过各种方法为患者导出。迄今为止，术前计算机断层扫描得出的骨骼肌测量结果显示与临床结果最一致。重要的是，骨骼肌可以通过抗阻训练和/或营养干预来改变。为了最终改善膀胱癌患者的临床结果，需要进行大规模的研究，不仅评估基线时身体成分特征的预后影响，还描述治疗后身体成分的变化。
Body size is emerging as a novel and clinically-relevant patient factor in bladder cancer research. Historically, a patient’s body mass index (BMI) has been used as a proxy for obesity but it shows inconsistent associations with risk of developing the disease as well as with most clinical outcomes. More specific body composition features can be derived for patients using a variety of methods. To date, skeletal muscle measurements derived from pre-operative computed tomography scans have shown the most consistent associations with clinical outcomes. Importantly, skeletal muscle can potentially be modified through resistance training and/or nutritional interventions. Large scale studies that evaluate the prognostic impact of not only body composition features at baseline but also describe changes in body composition post-treatment are needed to move the field forward to ultimately improve clinical outcomes for bladder cancer patients.
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影响因子：
3.3
作者：
Hariharan N;Ashcraft KA;Svatek RS;Livi CB;Wilson D;Kaushik D;Leach RJ;Johnson-Pais TL
通讯作者：
Johnson-Pais TL
DOI：
10.1002/jcsm.12279
发表时间：
2018-06
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Mayr R;Gierth M;Zeman F;Reiffen M;Seeger P;Wezel F;Pycha A;Comploj E;Bonatti M;Ritter M;van Rhijn BWG;Burger M;Bolenz C;Fritsche HM;Martini T
通讯作者：
Martini T
影响因子：
3.4
作者：
Ferro, Matteo;Vartolomei, Mihai Dorin;Lucarelli, Giuseppe
通讯作者：
Lucarelli, Giuseppe
影响因子：
3.2
作者：
McDonald, Michelle L.;Liss, Michael A.;Kader, A. Karim
通讯作者：
Kader, A. Karim
DOI：
10.3233/blc-180173
发表时间：
2018-10-29
期刊：
Bladder cancer (Amsterdam, Netherlands)
影响因子：
--
作者：
Arora K;Hanson KT;Habermann EB;Tollefson MK;Psutka SP
通讯作者：
Psutka SP