Thyroid stimulation by placental factors
Thyroid stimulation by placental factors
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胎盘因素刺激甲状腺
DOI：
--
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发表时间：
1993
影响因子：
5.4
通讯作者：
R. Hoermann
中科院分区：
文献类型：
--
作者：
K. Mann;R. Hoermann
现在有令人信服的证据表明，人胎盘产生的因子在正常妊娠期间对母体甲状腺功能有一定的调节作用，并能在一些孕妇和滋养细胞肿瘤患者中诱发明显的甲状腺功能亢进。就这些胎盘促甲状腺激素的生化性质而言，大量证据表明hCG是推定的促甲状腺因子，hCG在孕妇和滋养层疾病患者的血液中含量丰富，与人TSH有一些结构上的相似性。然而，令人不安的是，大多数体外研究都未能证明hCG确实能够刺激人体甲状腺。因此，除hCG外的其他因素也必须考虑，特别是一些促甲状腺活性增强的hCG分子变异形式。滋养层疾病患者中肿瘤相关hCG变异的存在及其在人甲状腺组织中刺激甲状腺激素释放的能力已被证实。更复杂的是，其他hCG的变体已经被鉴定出来，并从妊娠尿中纯化出来，它们对人甲状腺膜有抑制作用。hCG的变体形式已被证明与天然激素主要在碳水化合物部分不同，更酸性，更糖基化的变体是能够刺激人类甲状腺的变体，而更碱性的唾液酸缺乏变体，另一方面，是有效的甲状腺抑制剂。未来的研究应该揭示不同的甲状腺刺激剂和甲状腺抑制剂是否可能与人类TSH受体的特定区域相互作用，从而赋予它们各自的功能活性。不同hCG变体与刺激或抑制受体结构域的相互作用可以解释hCG及其变体形式的甲状腺调节作用的复杂性。
There is now convincing evidence that the human placenta produces factors which have some role in regulating maternal thyroid function during normal pregnancy and are capable of inducing overt hyperthyroidism in some pregnant women and in patients with trophoblastic tumors. As far as the biochemical nature of these placental thyroid stimulators is concerned, a bulk of evidence indicates that hCG, which is abundant in the blood of pregnant women and patients with trophoblastic diseases and shares some structural similarities with human TSH, is the putative thyroid-stimulating factor. However, it is disturbing that most in vitro studies have failed to prove that hCG is truly capable of stimulating the human thyroid. Therefore, factors other than hCG have also to be considered, particularly some molecular variant forms of hCG with enhanced thyrotropic activity. Both the existence of tumor-associated hCG variants in patients with trophoblastic diseases and their ability to stimulate thyroid hormone release in human thyroid tissue have been demonstrated. To complicate things further, other variants of hCG have been identified and purified from pregnancy urine that have a thyroid inhibitory effect in human thyroid membranes. The variant forms of hCG have been shown to differ from the native hormone mainly in the carbohydrate moiety, with the more acidic, more glycosylated variants being the ones capable of stimulating the human thyroid and the more alkaline sialic acidic deficient variants, on the other hand, being potent thyroid inhibitors. Future studies should reveal if the different thyroid stimulators and thyroid inhibitors may possibly interact with specific regions of the human TSH receptor that confer their respective functional activities. An interaction of different hCG variants with stimulatory or inhibitory receptor domains could explain the complex nature of the thyroid regulatory actions of hCG and its variant forms.
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有证据表明，人绒毛膜促性腺激素 (hCG) 的部分去唾液酸变体是粗 hCG 中抑制人甲状腺膜对促甲状腺素反应的因素。
影响因子：
4.8
作者：
Hoermann,R;Amir,SM;Ingbar,SH
通讯作者：
Ingbar,SH
人绒毛膜促性腺激素 (hCG) 直接与重组人 TSH 受体相互作用。
DOI：
10.1210/jcem.74.6.1317388
发表时间：
1992
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Tomer,Y;Huber,GK;Davies,TF
通讯作者：
Davies,TF
苯酚，人甲状腺膜中腺苷酸环化酶的有效刺激剂。
DOI：
10.1080/07435808109049840
发表时间：
1981
期刊：
Endocrine research communications
影响因子：
--
作者：
Amir,SM;Mulrow,NJ;Ingbar,SH
通讯作者：
Ingbar,SH
去唾液酸化对人绒毛膜促性腺激素与人甲状腺质膜体外相互作用的影响。
影响因子：
4.8
作者：
Amir,SM;Sullivan,R;Ingbar,SH
通讯作者：
Ingbar,SH
碳水化合物修饰将人绒毛膜促性腺激素转化为 3,5-单磷酸腺苷和 FRTL-5 甲状腺细胞生长反应的有效刺激剂。
影响因子：
4.8
作者：
Hoermann,R;Keutmann,HT;Amir,SM
通讯作者：
Amir,SM