Brain Iron Metabolism, Redox Balance and Neurological Diseases.
Brain Iron Metabolism, Redox Balance and Neurological Diseases.
复制标题
DOI：
10.3390/antiox12061289
复制
发表时间：
2023-06-16
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
帕金森氏症、阿尔茨海默病和中风等神经系统疾病的发病率正在增加。越来越多的研究将这些疾病与脑铁超载和由此造成的氧化损伤联系在一起。大脑缺铁也与神经发育密切相关。这些神经系统疾病严重影响患者的身心健康，给家庭和社会带来沉重的经济负担。因此，重要的是维持脑铁稳态，了解脑铁紊乱影响ROS平衡的机制，从而导致神经损伤、细胞死亡，最终导致疾病的发展。有证据表明，许多针对脑铁和ROS失衡的疗法对神经系统疾病具有良好的预防和治疗效果。本文就神经系统疾病中脑铁代谢紊乱的分子机制、发病机制及治疗策略作一综述。
The incidence of neurological diseases, such as Parkinson’s disease, Alzheimer’s disease and stroke, is increasing. An increasing number of studies have correlated these diseases with brain iron overload and the resulting oxidative damage. Brain iron deficiency has also been closely linked to neurodevelopment. These neurological disorders seriously affect the physical and mental health of patients and bring heavy economic burdens to families and society. Therefore, it is important to maintain brain iron homeostasis and to understand the mechanism of brain iron disorders affecting reactive oxygen species (ROS) balance, resulting in neural damage, cell death and, ultimately, leading to the development of disease. Evidence has shown that many therapies targeting brain iron and ROS imbalances have good preventive and therapeutic effects on neurological diseases. This review highlights the molecular mechanisms, pathogenesis and treatment strategies of brain iron metabolism disorders in neurological diseases.
登录
查看更多内容
影响因子：
15.1
作者：
Ayton S;Lei P;Adlard PA;Volitakis I;Cherny RA;Bush AI;Finkelstein DI
通讯作者：
Finkelstein DI
DOI：
10.1093/brain/awab191
发表时间：
2021-11-29
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Biondetti E;Santin MD;Valabrègue R;Mangone G;Gaurav R;Pyatigorskaya N;Hutchison M;Yahia-Cherif L;Villain N;Habert MO;Arnulf I;Leu-Semenescu S;Dodet P;Vila M;Corvol JC;Vidailhet M;Lehéricy S
通讯作者：
Lehéricy S
影响因子：
8
作者：
Andersen, Hjalte Holm;Johnsen, Kasper Bendix;Moos, Torben
通讯作者：
Moos, Torben
影响因子：
2.9
作者：
Basu, Sriparna;Kumar, Dinesh;Kumar, Ashok
通讯作者：
Kumar, Ashok
影响因子：
2.9
作者：
Callahan LS;Thibert KA;Wobken JD;Georgieff MK
通讯作者：
Georgieff MK