Left to themselves: Time to target chronic pain in childhood rare diseases.
Left to themselves: Time to target chronic pain in childhood rare diseases.
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留给自己：是时候针对儿童期稀有疾病的慢性疼痛的时候了。
DOI：
10.1016/j.neubiorev.2021.03.008
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发表时间：
2021-07
影响因子：
8.2
通讯作者：
Elman I
中科院分区：
文献类型：
--
作者：
Sieberg CB;Lebel A;Silliman E;Holmes S;Borsook D;Elman I
慢性疼痛在罕见病（RD）患者中普遍存在。然而，很少有人了解如何生物心理社会机制可能会被整合在一套独特的临床特征和治疗的挑战，固有的疼痛条件。这篇综述介绍了具有特定疼痛条件的主要类别的RD的示例。此外，我们还提供了关于RD患者疼痛的心理社会和神经发育知情治疗的临床和科学依据的转化证据。各种RD综合征和疼痛状态之间的神经生物学和功能重叠表明了各自条件的合并和相互调节。情绪后遗症可以被解释为通过重叠的大脑回路介导的身体疼痛的情绪同源物。鉴于其明确定义的遗传和分子病因学，RD可以作为启发式模型解开慢性疼痛固有的病理生理过程。对RD患者慢性疼痛的系统评价有助于对疼痛及其心理社会相关性的深入了解，这可能会改变治疗。
Chronic pain is prevalent among patients with rare diseases (RDs). However, little is understood about how biopsychosocial mechanisms may be integrated in the unique set of clinical features and therapeutic challenges inherent in their pain conditions. This review presents examples of major categories of RDs with particular pain conditions. In addition, we provide translational evidence on clinical and scientific rationale for psychosocially- and neurodevelopmentally-informed treatment of pain in RD patients. Neurobiological and functional overlap between various RD syndromes and pain states suggests amalgamation and mutual modulation of the respective conditions. Emotional sequelae could be construed as an emotional homologue of physical pain mediated via overlapping brain circuitry. Given their clearly defined genetic and molecular etiologies, RDs may serve as heuristic models for unraveling pathophysiological processes inherent in chronic pain. Systematic evaluation of chronic pain in patients with RD contributes to sophisticated insight into both pain and their psychosocial correlates, which could transform treatment.
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影响因子：
7.4
作者：
Borsook D;Youssef AM;Simons L;Elman I;Eccleston C
通讯作者：
Eccleston C
影响因子：
4.7
作者：
Arnstad, Ellen Dalen;Rypdal, Veronika;Pelkonen, Pirkko
通讯作者：
Pelkonen, Pirkko
影响因子：
3.7
作者：
Attarian, Shahram;Vallat, Jean-Michel;Cohen, Daniel
通讯作者：
Cohen, Daniel
DOI：
10.1177/2470547017704763
发表时间：
2017-03
期刊：
Chronic stress (Thousand Oaks, Calif.)
影响因子：
--
作者：
Abdallah CG;Geha P
通讯作者：
Geha P
影响因子：
3.6
作者：
Brattberg, G
通讯作者：
Brattberg, G