Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
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DOI：
10.3389/fcell.2022.1056523
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
细胞外基质(ECM)是一个相互连接的大分子支架，占据了细胞之间的空间。在其他功能中，ECM为组织提供结构支持，并作为向细胞传递调节信号的微环境利基。连接细胞外基质和细胞骨架的细胞-基质黏附是一种动态的多蛋白质复合体，含有表面受体和细胞内效应物，控制着各种下游途径。在骨骼肌中，身体最丰富的组织，每个单独的肌肉纤维及其相关的肌肉干细胞(MuSCs)被一层被称为基板的细胞外基质所包围。基膜的核心支架由自组装的聚合物层粘连蛋白和胶原蛋白网络组成，胶原蛋白网络连接蛋白多糖，提供侧向交联，与细胞表面受体建立侧支联系，并充当生长因子的接收器和储存库。骨骼肌还含有纤维状胶原间质ECM，它在决定组织弹性方面起着重要作用，连接着基底板，并含有分泌基质的间质成纤维细胞样细胞类型和血管。在骨骼肌再生过程中，成纤维细胞样细胞群扩大，并促进富含纤维连接蛋白的过渡性再生基质，从而指导血管生成和MUSC功能。在这里，我们提供了骨骼肌细胞外基质在健康和疾病中的作用的全面概述，并概述了它在组织再生和MUSC功能中的作用。
The extracellular matrix (ECM) is an interconnected macromolecular scaffold occupying the space between cells. Amongst other functions, the ECM provides structural support to tissues and serves as a microenvironmental niche that conveys regulatory signals to cells. Cell-matrix adhesions, which link the ECM to the cytoskeleton, are dynamic multi-protein complexes containing surface receptors and intracellular effectors that control various downstream pathways. In skeletal muscle, the most abundant tissue of the body, each individual muscle fiber and its associated muscle stem cells (MuSCs) are surrounded by a layer of ECM referred to as the basal lamina. The core scaffold of the basal lamina consists of self-assembling polymeric laminins and a network of collagens that tether proteoglycans, which provide lateral crosslinking, establish collateral associations with cell surface receptors, and serve as a sink and reservoir for growth factors. Skeletal muscle also contains the fibrillar collagenous interstitial ECM that plays an important role in determining tissue elasticity, connects the basal laminae to each other, and contains matrix secreting mesenchymal fibroblast-like cell types and blood vessels. During skeletal muscle regeneration fibroblast-like cell populations expand and contribute to the transitional fibronectin-rich regenerative matrix that instructs angiogenesis and MuSC function. Here, we provide a comprehensive overview of the role of the skeletal muscle ECM in health and disease and outline its role in orchestrating tissue regeneration and MuSC function.
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影响因子：
4.9
作者：
Allamand V;Briñas L;Richard P;Stojkovic T;Quijano-Roy S;Bonne G
通讯作者：
Bonne G
影响因子：
5.3
作者：
Ceafalan LC;Dobre M;Milanesi E;Niculae AM;Manole E;Gherghiceanu M;Hinescu ME
通讯作者：
Hinescu ME
影响因子：
5.2
作者：
Allamand, V;Guicheney, P
通讯作者：
Guicheney, P
影响因子：
3.5
作者：
Bonaldo, P;Braghetta, P;Bressan, GM
通讯作者：
Bressan, GM
影响因子：
5.5
作者：
Becsky D;Szabo K;Gyulai-Nagy S;Gajdos T;Bartos Z;Balind A;Dux L;Horvath P;Erdelyi M;Homolya L;Keller-Pinter A
通讯作者：
Keller-Pinter A