Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer.
Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer.
复制标题
通过碳水化合物和脂肪代谢调节癌症中的自噬。
作者：
碳水化合物和脂质的代谢对于满足细胞的各种需求至关重要。自噬细胞通路通过其靶向和降解受损细胞器和错误折叠蛋白的能力对正常细胞功能至关重要。自噬还为细胞提供必要的能量作为最终产品。癌细胞具有高增殖率，因此与正常细胞相比需要更多的能量。毫不奇怪，癌细胞高度依赖于这些代谢途径。这篇综述对最近关于碳水化合物和脂质代谢如何调节自噬以及这如何影响癌细胞的研究结果进行了深入的回顾。代谢变化是肿瘤细胞进展的重要组成部分。肿瘤细胞通过改变碳水化合物和脂质代谢来适应环境压力。自噬是哺乳动物细胞中通过溶酶体降解破坏细胞器和错误折叠蛋白质的生理过程，与哺乳动物细胞的代谢密切相关，充当细胞ATP水平的仪表。在这篇综述中，我们讨论了哺乳动物细胞中糖酵解和脂质生物合成途径的变化及其通过自噬途径对癌变的影响。此外，我们还讨论了这些代谢途径对肺癌自噬的影响。
The metabolism of carbohydrates and lipids is essential to meet the diverse needs of cells. The autophagy cellular pathway is crucial for normal cellular function through its ability to target and degrade damaged organelles and misfolded proteins. Autophagy also provides cells with necessary energy as an end product. Cancer cells have a high rate of proliferation and, thus, require more energy compared to normal cells. Not surprisingly, cancer cells are highly dependent on these metabolic pathways. This review provides an in-depth review of recent research findings on how carbohydrate and lipid metabolism regulate autophagy and how this impacts cancer cells. Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer.
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影响因子：
8.8
作者：
通讯作者：
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4.8
作者：
Aguado, B;Campbell, RD
通讯作者：
Campbell, RD
影响因子：
5
作者：
Araki, Makoto;Maeda, Masatomo;Motojima, Kiyoto
通讯作者：
Motojima, Kiyoto
影响因子：
5.6
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Barzegar Behrooz A;Talaie Z;Jusheghani F;Łos MJ;Klonisch T;Ghavami S
通讯作者：
Ghavami S
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4.6
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Alizadeh J;Zeki AA;Mirzaei N;Tewary S;Rezaei Moghadam A;Glogowska A;Nagakannan P;Eftekharpour E;Wiechec E;Gordon JW;Xu FY;Field JT;Yoneda KY;Kenyon NJ;Hashemi M;Hatch GM;Hombach-Klonisch S;Klonisch T;Ghavami S
通讯作者：
Ghavami S