Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer.
Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer.
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维生素D：承诺在地平线上，对抗胰腺癌的挑战。
DOI：
10.3390/cancers13112716
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发表时间：
2021-05-31
期刊：
影响因子：
5.2
通讯作者：
Bresalier RS
中科院分区：
文献类型：
--
作者：
Wei D;Wang L;Zuo X;Bresalier RS
胰腺癌是一种几乎普遍致命的癌症，主要是由于其诊断晚，早期转移和治疗抗性。这突出了需要开发新的和有效的干预策略，以改善胰腺癌患者的结果。维生素D是癌症研究和临床中最热门的话题之一，因为它对癌症的标志具有多效性功能。在这里，我们批判性地回顾了过去和目前的努力，确定维生素D对胰腺癌的风险，发病率，患者生存率和死亡率的影响。我们还概述了与维生素D相关的机遇和挑战，作为一种经济辅助手段，以提高胰腺癌免疫治疗和化疗或放疗的疗效。 胰腺癌的预后很差，但其发病率却在不断上升。这部分归因于与这种癌症相关的深刻的促纤维增生和免疫抑制肿瘤微环境以及对当前可用疗法的抗性。因此，迫切需要新的有效的干预策略来改善胰腺癌患者的预后。维生素D具有超越钙-磷酸盐稳态的多效性功能，并且作为潜在的预防剂或标准疗法的辅助剂在实验室和临床中被广泛研究。从生态学、观察性和随机对照试验中积累的证据表明，维生素D对胰腺癌的风险、生存率和死亡率有有益的影响，尽管仍存在争议。最近在证明维生素D/维生素D受体（VDR）信号传导在调节基质重编程，微生物组和免疫应答中的重要功能以及检查点免疫疗法的出现方面取得的进展为使用维生素D或其类似物作为胰腺癌干预的辅助手段提供了机会。在胰腺癌中充分实现维生素D的益处之前，还有许多挑战。这些挑战包括需要进行维生素D的随机对照试验，以评估其对胰腺癌风险和生存率的影响，优化维生素D或其类似物作为胰腺癌干预辅助药物的时机和剂量，并阐明维生素D/VDR信号在胰腺癌不同阶段的具体作用。然而，维生素D在降低风险和改善这种疾病的结果方面具有很大的潜力。
Pancreatic cancer is an almost universally lethal cancer, largely due to its late diagnosis, early metastasis, and therapeutic resistance. This highlights the need to develop novel and effective intervention strategies to improve the outcomes of patients with pancreatic cancer. Vitamin D is one of the hottest topics in cancer research and clinics because of its pleiotropic functions on the hallmarks of cancer. Here we critically review past and current efforts that define the effects of vitamin D on the risk, incidence, patient survival, and mortality of pancreatic cancer. We also provide overviews on the opportunities and challenges associated with vitamin D as an economic adjunct to improve the efficacy of immunotherapy and chemo- or radiotherapy for pancreatic cancer. Pancreatic cancer has a dismal prognosis, while its incidence is increasing. This is attributed, in part, to a profound desmoplastic and immunosuppressive tumor microenvironment associated with this cancer and resistance to current available therapies. Novel and effective intervention strategies are urgently needed to improve the outcomes of patients with pancreatic cancer. Vitamin D has pleiotropic functions beyond calcium–phosphate homeostasis and has been extensively studied both in the laboratory and clinic as a potential preventive agent or adjunct to standard therapies. Accumulating evidence from ecological, observational, and randomized controlled trials suggests that vitamin D has beneficial effects on risk, survival, and mortality in pancreatic cancer, although controversies still exist. Recent advances in demonstrating the important functions of vitamin D/vitamin D receptor (VDR) signaling in the regulation of stromal reprogramming, the microbiome, and immune response and the emergence of checkpoint immunotherapy provide opportunities for using vitamin D or its analogues as an adjunct for pancreatic cancer intervention. Many challenges lie ahead before the benefits of vitamin D can be fully realized in pancreatic cancer. These challenges include the need for randomized controlled trials of vitamin D to assess its impact on the risk and survival of pancreatic cancer, optimizing the timing and dosage of vitamin D or its analogues as an adjunct for pancreatic cancer intervention and elucidating the specific role of vitamin D/VDR signaling in the different stages of pancreatic cancer. Nevertheless, vitamin D holds great promise for reducing risk and improving outcomes of this disease.
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DOI：
10.4161/19381980.2014.983401
发表时间：
2014-01
期刊：
Dermato-endocrinology
影响因子：
--
作者：
Cannell JJ;Grant WB;Holick MF
通讯作者：
Holick MF
影响因子：
7.4
作者：
Cho M;Peddi PF;Ding K;Chen L;Thomas D;Wang J;Lockhart AC;Tan B;Wang-Gillam A
通讯作者：
Wang-Gillam A
维生素D受体信号传导和癌症。
DOI：
10.1016/j.ecl.2017.07.007
发表时间：
2017-12
影响因子：
4.5
作者：
Campbell MJ;Trump DL
通讯作者：
Trump DL
影响因子：
24.5
作者：
Crockett SD;Barry EL;Mott LA;Ahnen DJ;Robertson DJ;Anderson JC;Wallace K;Burke CA;Bresalier RS;Figueiredo JC;Snover DC;Baron JA
通讯作者：
Baron JA
影响因子：
5.8
作者：
Barry, Elizabeth L.;Rees, Judy R.;Baron, John A.
通讯作者：
Baron, John A.