Vitamin D deficiency and prognostics among patients with pancreatic adenocarcinoma.
Vitamin D deficiency and prognostics among patients with pancreatic adenocarcinoma.
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DOI：
10.1186/1479-5876-11-206
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发表时间：
2013-09-08
影响因子：
7.4
通讯作者：
Wang-Gillam A
中科院分区：
文献类型：
--
作者：
Cho M;Peddi PF;Ding K;Chen L;Thomas D;Wang J;Lockhart AC;Tan B;Wang-Gillam A
癌症患者中维生素D缺乏症的患病率以前已有报道。由于维生素D是脂溶性的，胰腺癌患者可能具有特别高的维生素D缺乏风险，并伴有持续和不同程度的吸收不良。然而，很少有人知道维生素D状态和预后之间的相关性，在这些患者。我们对在Siteman癌症中心接受治疗的胰腺癌患者的维生素D状况进行了回顾性分析。收集患者的人口统计学信息、维生素D评估时的临床分期、维生素D水平和生存数据。维生素D缺乏定义为血清25-羟基维生素D（25[OH]D）水平低于20 ng/mL，维生素D不足定义为25（OH）D水平介于20 ng/mL和30 ng/mL之间。2007年12月至2011年6月期间，178名胰腺癌患者在该中心首次就诊时检查了维生素D水平。在这178例患者中，87例（49%）维生素D缺乏，44例（25%）维生素D不足。在非白人患者和I期和II期疾病患者中，25（OH）D水平中位数显著较低。在III期和IV期疾病患者中，发现25（OH）D水平低于20 ng/mL与预后不良相关（p = 0.0019）。维生素D不足和缺乏在胰腺癌患者中普遍存在。维生素D水平似乎是晚期胰腺癌患者的预后，其影响应在前瞻性研究中进一步检查。
The prevalence of vitamin D deficiency among patients with cancer has been previously reported. Because vitamin D is fat soluble, patients with pancreatic adenocarcinoma may have an especially high risk of vitamin D deficiency in association with ongoing and varying degrees of malabsorption. However, little is known about the correlation between vitamin D status and prognosis in these patients. We conducted a retrospective review of vitamin D status in patients with pancreatic adenocarcinoma who were treated at Siteman Cancer Center. Patients’ demographic information, clinical staging at the time of vitamin D assessment, vitamin D levels, and survival data were collected. Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D (25[OH]D) level of less than 20 ng/mL, and vitamin D insufficiency was defined as a 25(OH)D level of between 20 ng/mL and 30 ng/mL. Between December 2007 and June 2011, 178 patients with pancreatic adenocarcinoma had their vitamin D levels checked at the time of initial visit at this center. Of these 178 patients, 87 (49%) had vitamin D deficiency, and 44 (25%) had vitamin D insufficiency. The median 25(OH)D level was significantly lower among nonwhite patients and among patients with stage I and II disease. A 25(OH)D level of less than 20 ng/mL was found to be associated with poor prognosis (p = 0.0019) in patients with stage III and IV disease. Vitamin D insufficiency and deficiency were prevalent among patients with pancreatic adenocarcinoma. The vitamin D level appears to be prognostic for patients with advanced pancreatic adenocarcinoma, and its effects should be further examined in a prospective study.
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DOI：
10.1158/1055-9965.epi-11-0836
发表时间：
2012-01
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Wolpin BM;Ng K;Bao Y;Kraft P;Stampfer MJ;Michaud DS;Ma J;Buring JE;Sesso HD;Lee IM;Rifai N;Cochrane BB;Wactawski-Wende J;Chlebowski RT;Willett WC;Manson JE;Giovannucci EL;Fuchs CS
通讯作者：
Fuchs CS
影响因子：
5.6
作者：
Giovannucci, Edward
通讯作者：
Giovannucci, Edward
影响因子：
4.5
作者：
Forrest, Kimberly Y. Z.;Stuhldreher, Wendy L.
通讯作者：
Stuhldreher, Wendy L.
维生素D途径基因的遗传变异和胰腺癌的风险；来自加拿大安大略省的基于人群的病例对照研究的结果。
影响因子：
3.7
作者：
Anderson LN;Cotterchio M;Knight JA;Borgida A;Gallinger S;Cleary SP
通讯作者：
Cleary SP
影响因子：
2.3
作者：
Tretli, Steinar;Schwartz, Gary G.;Torjesen, Peter Abusdal;Robsahm, Trude Eid
通讯作者：
Robsahm, Trude Eid