Regulatory T cells in renal disease.
Regulatory T cells in renal disease.
复制标题
DOI：
10.1002/cti2.1004
复制
发表时间：
2018
影响因子：
5.8
通讯作者：
Ooi JD
中科院分区：
文献类型：
--
作者：
Alikhan MA;Huynh M;Kitching AR;Ooi JD
肾脏容易受到各种免疫和代谢损伤的急性和慢性损伤，所有这些损伤至少在一定程度上都涉及炎症。调节性T细胞调节肾小球肾炎和移植中的系统性自身免疫和同种异体反应。肾内调节性T细胞（TCRs），包括那些募集到肾脏，具有抑制作用的适应性和先天性免疫细胞，也可能是内在的肾细胞。来自自身免疫性肾小球肾炎的证据表明抗原特异性T细胞参与HLA介导的显性保护，而在几种人类肾脏疾病中，T细胞数量或表型异常。在实验中，TdR可以保护肾脏免受各种肾脏疾病的损伤。Treg向肾脏募集的机制包括通过趋化因子受体CCR 6和CXCR 3，并且至少在先天性损伤TLR 9中可能。Tbet的作用可能是环境依赖性的，有证据表明内源性Tbet表达Tbet和STAT-3表达Tbet在实验性肾小球肾炎中均具有免疫调节作用。大多数实验工作和一些正在进行的人体肾移植试验都集中在未分级胸腺来源的胸腺肽（tTHBG）。然而，诱导型T细胞（iT细胞）、1型调节性T细胞（Tr 1），特别是抗原特异性T细胞不仅在肾移植中，而且在其他肾脏疾病中也具有治疗潜力。
The kidney is vulnerable to injury, both acute and chronic from a variety of immune and metabolic insults, all of which at least to some degree involve inflammation. Regulatory T cells modulate systemic autoimmune and allogenic responses in glomerulonephritis and transplantation. Intrarenal regulatory T cells (Tregs), including those recruited to the kidney, have suppressive effects on both adaptive and innate immune cells, and probably also intrinsic kidney cells. Evidence from autoimmune glomerulonephritis implicates antigen‐specific Tregs in HLA‐mediated dominant protection, while in several human renal diseases Tregs are abnormal in number or phenotype. Experimentally, Tregs can protect the kidney from injury in a variety of renal diseases. Mechanisms of Treg recruitment to the kidney include via the chemokine receptors CCR6 and CXCR3 and potentially, at least in innate injury TLR9. The effects of Tregs may be context dependent, with evidence for roles for immunoregulatory roles both for endogenous Tbet‐expressing Tregs and STAT‐3‐expressing Tregs in experimental glomerulonephritis. Most experimental work and some of the ongoing human trials in renal transplantation have focussed on unfractionated thymically derived Tregs (tTregs). However, induced Tregs (iTregs), type 1 regulatory T (Tr1) cells and in particular antigen‐specific Tregs also have therapeutic potential not only in renal transplantation, but also in other kidney diseases.
登录
查看更多内容
影响因子：
3.1
作者：
Daniel, Volker;Naujokat, Cord;Opelz, Gerhard
通讯作者：
Opelz, Gerhard
影响因子：
4.4
作者：
Bestard, Oriol;Cruzado, Josep M.;Grinyo, Josep M.
通讯作者：
Grinyo, Josep M.
影响因子：
1.5
作者：
Daniel, Volker;Sadeghi, Mahmoud;Opelz, Gerhard
通讯作者：
Opelz, Gerhard
影响因子：
5.5
作者：
Ascon, Dolores B.;Ascon, Miguel;Rabb, Hamid
通讯作者：
Rabb, Hamid
影响因子：
13.6
作者：
Chang, Janet;Eggenhuizen, Peter;Kitching, A. Richard
通讯作者：
Kitching, A. Richard