MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance.
MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance.
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DOI：
10.1007/s00428-016-1970-5
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发表时间：
2016-09
期刊：
影响因子：
3.5
通讯作者：
Langner, Cord
中科院分区：
文献类型：
--
作者：
Betge, Johannes;Schneider, Nora I.;Harbaum, Lars;Pollheimer, Marion J.;Lindtner, Richard A.;Kornprat, Peter;Ebert, Matthias P.;Langner, Cord
在致癌过程中，粘蛋白糖蛋白的表达会发生改变。对结直肠癌（CRC）患者预后的影响存在争议。我们使用组织微阵列，通过免疫组织化学染色分析了381例患者肿瘤的MUC 1、MUC 2、MUC 5AC和MUC 6表达。使用Kaplan-Meier方法确定无进展生存期和癌症特异性生存期。肠粘蛋白MUC 2的表达在85例（23%）CRC中丢失，MUC 6阴性肿瘤患者的无进展生存期较短（PFS，p = 0.043）。胃粘蛋白MUC 5AC和MUC 6分别在28例（8%）和9例（2%）病例中显示高（> 50%）异常表达。MUC 5AC的高表达与较长的PFS相关（p = 0.055）。MUC 6的高表达与100%PFS（p = 0.024）和更长的癌症特异性生存期（CSS，p = 0.043）相关。MUC 1在238例（64%）肿瘤中表达，对结局无影响。当分析仅限于II期和III期时，MUC 2的丢失与不良结局相关。MUC 5AC和MUC 6两者的过表达显著预测有利的PFS和CSS。总之，MUC 2表达的缺失被证明是不良结局的预测因子，而MUC 5AC特别是MUC 6异常表达的获得与CRC的有利结局相关，特别是在中期II和III期。
Mucin glycoprotein expression can be altered during the carcinogenic process. The impact on the prognosis of patients with colorectal cancer (CRC) is controversial. We analyzed tumors from 381 patients for MUC1, MUC2, MUC5AC, and MUC6 expression by immunohistochemical staining, using tissue microarrays. Progression-free and cancer-specific survival were determined using the Kaplan-Meier method. Expression of intestinal mucin MUC2 was lost in 85 (23 %) CRCs, and patients with MUC6-negative tumors showed shorter progression-free survival (PFS, p = 0.043). Gastric mucins MUC5AC and MUC6 showed high (>50 %) aberrant expression in 28 (8 %) and 9 (2 %) cases, respectively. High expression of MUC5AC was associated with longer PFS (p = 0.055). High expression of MUC6 was associated with 100 % PFS (p = 0.024) and longer cancer-specific survival (CSS, p = 0.043). MUC1 was expressed in 238 (64 %) tumors and had no impact on outcome. When analysis was restricted to stages II and III, loss of MUC2 was associated with adverse outcome. Overexpression of both MUC5AC and MUC6 significantly predicted favorable PFS and CSS. In conclusion, loss of MUC2 expression proved to be a predictor of adverse outcome, while the gain of aberrant expression of MUC5AC and particularly of MUC6 was associated with favorable outcome in CRC, notably in intermediate stages II and III.
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影响因子：
6.4
作者：
Harbaum, Lars;Pollheimer, Marion J.;Langner, Cord
通讯作者：
Langner, Cord
影响因子：
11.5
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7.5
作者：
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Terracciano, Luigi Maria
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作者：
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通讯作者：
Pyrhonen, Seppo
影响因子：
4.3
作者：
Imai，Yasuo;Yamagishi，Hidetsugu;Ueda，Yoshihiko
通讯作者：
Ueda，Yoshihiko