Application of Stem Cell Therapy for Infertility.
Application of Stem Cell Therapy for Infertility.
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DOI：
10.3390/cells10071613
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发表时间：
2021-06-28
期刊：
影响因子：
6
通讯作者：
Kakar SS
中科院分区：
文献类型：
--
作者：
Saha S;Roy P;Corbitt C;Kakar SS
不孕症对受影响夫妇的心理健康产生巨大影响，导致生活质量低下。不孕症现在被认为是一个全球性的健康问题，影响着全球约15%的夫妇。它可能由男性（30%）相关因素引起，包括精索静脉曲张，隐睾，睾丸癌和无精子症;女性（30%），包括卵巢早衰和子宫疾病;或双方（30%）。随着辅助生殖技术（ART）的发展，许多受影响的夫妇（80%）可以找到解决方案。然而，相当数量的夫妇不能怀孕，即使在ART。干细胞现在越来越多地被调查作为有前途的替代疗法在再生医学的转化研究。在理解干细胞的生物学和功能方面已经取得了巨大的进展。考虑到最低限度的伦理问题和容易获得的丰富资源，人们正在对诱导多能干细胞（iPSC）和间充质干细胞（MSC）进行广泛的研究，以了解其在生殖医学中的潜在应用，特别是在无精子症和卵巢功能不全导致的不孕症的情况下。然而，大多数这些研究都是在动物模型中进行的。在动物和人类多能性中观察到的进化差异需要谨慎外推从小鼠模型获得的数据，以将其安全地应用于人类临床应用。因此，需要开展更多基于更大人群的临床试验，以研究干细胞治疗在转化不孕症医学中的相关性，包括其安全性和有效性。
Infertility creates an immense impact on the psychosocial wellbeing of affected couples, leading to poor quality of life. Infertility is now considered to be a global health issue affecting approximately 15% of couples worldwide. It may arise from factors related to the male (30%), including varicocele, undescended testes, testicular cancer, and azoospermia; the female (30%), including premature ovarian failure and uterine disorders; or both partners (30%). With the recent advancement in assisted reproduction technology (ART), many affected couples (80%) could find a solution. However, a substantial number of couples cannot conceive even after ART. Stem cells are now increasingly being investigated as promising alternative therapeutics in translational research of regenerative medicine. Tremendous headway has been made to understand the biology and function of stem cells. Considering the minimum ethical concern and easily available abundant resources, extensive research is being conducted on induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSC) for their potential application in reproductive medicine, especially in cases of infertility resulting from azoospermia and premature ovarian insufficiency. However, most of these investigations have been carried out in animal models. Evolutionary divergence observed in pluripotency among animals and humans requires caution when extrapolating the data obtained from murine models to safely apply them to clinical applications in humans. Hence, more clinical trials based on larger populations need to be carried out to investigate the relevance of stem cell therapy, including its safety and efficacy, in translational infertility medicine.
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DOI：
10.1186/s12958-015-0104-2
发表时间：
2015-09-23
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Damous LL;Nakamuta JS;Carvalho AE;Carvalho KC;Soares JM Jr;Simões Mde J;Krieger JE;Baracat EC
通讯作者：
Baracat EC
影响因子：
3.7
作者：
Alawadhi F;Du H;Cakmak H;Taylor HS
通讯作者：
Taylor HS
影响因子：
7.5
作者：
Cao Y;Sun H;Zhu H;Zhu X;Tang X;Yan G;Wang J;Bai D;Wang J;Wang L;Zhou Q;Wang H;Dai C;Ding L;Xu B;Zhou Y;Hao J;Dai J;Hu Y
通讯作者：
Hu Y
影响因子：
6
作者：
de Miguel-Gómez L;López-Martínez S;Francés-Herrero E;Rodríguez-Eguren A;Pellicer A;Cervelló I
通讯作者：
Cervelló I
影响因子：
5.8
作者：
Cheng, Yee Chung;Takagi, Mariko;Ueno, Naoto T.
通讯作者：
Ueno, Naoto T.