Recombinant human megakaryocyte growth and development factor increases levels of circulating haemopoietic progenitor cells post chemotherapy in patients with acute myeloid leukaemia
Recombinant human megakaryocyte growth and development factor increases levels of circulating haemopoietic progenitor cells post chemotherapy in patients with acute myeloid leukaemia
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重组人巨核细胞生长发育因子可增加急性髓系白血病患者化疗后循环造血祖细胞的水平
DOI：
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发表时间：
1998
影响因子：
6.5
通讯作者：
K. Lechner
中科院分区：
文献类型：
--
作者：
K. Geissler;E. Kabrna;Susanna Stengg;I. Schwarzinger;P. Knöbl;P. Valent;S. Eichinger;A. Barge;K. Lechner
通过参加聚乙二醇化重组人巨核细胞生长发育因子(PEGrHuMGDF)诱导巩固化疗后治疗初治急性髓系白血病的随机安全性和有效性研究，在8例患者(3例接受安慰剂，1例，2.5，4例，5.0 μg/kg/d MGDF)的18个化疗疗程中进行了一系列的循环造血祖细胞测定。完全缓解(CR)失败通常与化疗后祖细胞增加不足有关，但在进入或CR患者的造血恢复过程中，大量祖细胞动员一直存在，接受5 μg/kg/d的MGDF的患者的峰值明显高于对照组。单用化疗和化疗加5.0mGDF5.0 μg/kg/d的造血祖细胞数的中位数分别是正常对照组的10倍和45倍，3倍和17倍，2倍和18倍。单用化疗并不能使CFU-Mk水平高于正常水平，但化疗加MGDF可使CFU-Mk水平提高15倍。化疗后CD34+细胞的募集也被MGDF增强。我们的结果提示MGDF是一种在AML患者成功诱导或巩固化疗后增强祖细胞动员的有效药物。
By participating in a randomized safety and efficacy study of pegylated‐recombinant human megakaryocyte growth and development factor (PEG‐rHuMGDF) post induction and consolidation chemotherapy for de novo acute myeloid leukaemia, serial determinations of circulating haemopoietic progenitor cells were performed during 18 chemotherapy courses in eight patients (three receiving placebo; one, 2.5; and four, 5.0 μg/kg/d MGDF, respectively). Whereas failure to achieve complete remission (CR) was generally associated with poor progenitor cell increments following chemotherapy, substantial progenitor cell mobilization consistently occurred during haemopoietic recovery in patients entering, or in CR, with significantly higher peak values in patients receiving 5 μg/kg/d of MGDF as compared to controls. The median increases of progenitor cell numbers by chemotherapy alone and chemotherapy plus 5.0 μg/kg/d MGDF over that in normal individuals with steady‐state haemopoiesis were 10‐ and 45‐fold for CFU‐GM, 3‐ and 17‐fold for BFU‐E, and 2‐ and 18‐fold for CFU‐mix. CFU‐Mk levels were not increased above normal by chemotherapy alone but were 15‐fold enhanced by chemotherapy plus MGDF. Recruitment of CD34+ cells post chemotherapy was also potentiated by MGDF. Our results suggest MGDF as a potent agent to augment progenitor cell mobilization after successful induction or consolidation chemotherapy in patients with AML.
通过化疗和粒细胞-巨噬细胞集落刺激因子动员外周血祖细胞，在乳腺癌高剂量强化治疗后提供血液支持。
影响因子：
20.3
作者：
Elias,AD;Ayash,L;Anderson,KC;Hunt,M;Wheeler,C;Schwartz,G;Tepler,I;Mazanet,R;Lynch,C;Pap,S
通讯作者：
Pap,S
DOI：
10.1073/pnas.91.23.11104
发表时间：
1994-11-08
影响因子：
11.1
作者：
KUTER, DJ;BEELER, DL;ROSENBERG, RD
通讯作者：
ROSENBERG, RD
粒细胞-巨噬细胞集落刺激因子（GM-CSF）和粒细胞集落刺激因子（G-CSF）对高剂量化疗后用于自体骨髓的外周血祖细胞的启动作用的比较。
影响因子：
20.3
作者：
Peters,WP;Rosner,G;Ross,M;Vredenburgh,J;Meisenberg,B;Gilbert,C;Kurtzberg,J
通讯作者：
Kurtzberg,J