Management of Peripheral T-cell Lymphomas and the Role of Transplant.
Management of Peripheral T-cell Lymphomas and the Role of Transplant.
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DOI：
10.1007/s11912-022-01310-3
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发表时间：
2022-11
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
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作者：
外周t细胞淋巴瘤是一种罕见的非霍奇金淋巴瘤，其治疗目的是治愈。虽然治疗基于其他侵袭性淋巴细胞恶性肿瘤，但结果通常比b细胞淋巴瘤差，5年总生存率和无进展生存率分别为30-40%和20-30%。为了改善预后，移植已在一线和抢救环境中使用。虽然没有在随机研究中进行研究，但首次缓解时进行自体干细胞移植的巩固与大约50-60%的5年总生存率和40-45%的5年无进展生存率相关。不幸的是，大多数患者会复发，在这种情况下，同种异体移植仍然是那些符合移植条件的患者唯一的治疗选择。多个系列现已显示同种异体移植的3年总生存率约为60%。然而，移植的结果与移植时的疾病控制有关。
Peripheral T-cell lymphomas are a rare subset of non-Hodgkin lymphomas that are treated with curative intent. While therapy has been based on other aggressive lymphoid malignancies, outcomes are generally poorer than B-cell lymphomas with 5-year overall and progression free survival 30–40% and 20–30%, respectively. In effort to improve outcomes, transplant has been used in both the frontline and salvage settings. Although not studied in randomized studies, consolidation with autologous stem cell transplant in first remission has been associated with an approximately 50–60% 5-year overall survival and 40–45% 5-year progression free survival. Unfortunately, most patients relapse, and, in this setting, allogeneic transplant remains the only curative option for those who are transplant eligible. Multiple series have now shown that 3-year overall survival with allogeneic transplant is approximately 60%. However, outcomes with transplant are associated with disease control at the time of transplant.
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影响因子：
10.1
作者：
Bellei M;Foss FM;Shustov AR;Horwitz SM;Marcheselli L;Kim WS;Cabrera ME;Dlouhy I;Nagler A;Advani RH;Pesce EA;Ko YH;Martinez V;Montoto S;Chiattone C;Moskowitz A;Spina M;Biasoli I;Manni M;Federico M;International T-cell Project Network
通讯作者：
International T-cell Project Network
DOI：
10.1016/j.annonc.2021.12.002
发表时间：
2022-03
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
通讯作者：
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影响因子：
4.3
作者：
Chen, Andy I.;McMillan, Alex;Neprin, Robert S.;Horning, Sandra J.;Laport, Ginna G.
通讯作者：
Laport, Ginna G.
影响因子：
28.5
作者：
Foss F;Horwitz S;Pro B;Prince HM;Sokol L;Balser B;Wolfson J;Coiffier B
通讯作者：
Coiffier B
影响因子：
13.8
作者：
Du J;Yu D;Han X;Zhu L;Huang Z
通讯作者：
Huang Z